Psoriasis is one of the most frequent inflammatory skin disorders in Caucasians. It is a genetically determined disease that affects the skin, scalp and nails. It is characterized by sharply demarcated erythematous plaques with silvery scales, which appear typically on the knees, elbows, sacral region and scalp, but the entire skin may be involved. Nail changes include distal onycholysis, pitti...

OBJECTIVE AND METHODS This health technology assessment (HTA) report synthesises systematically randomized controlled studies (RCT) on the therapy of moderate and severe psoriasis vulgaris which were published between 1999 and 2004; it includes some important clinical studies which have been published after 2004 and thus updates the English HTA report by Griffiths et al. [1]. The major objectiv...

Between 1976 and 1988, 50 primary total knee arthroplasties were performed on 34 patients with psoriasis vulgaris. The skin lesions were graded for severity in all patients and the extent of affected body surface was mapped. All patients received peri-operative antibiotics. Only one deep infection, with Staphylococcus aureus, occurred 25 months after operation. The average length of follow-up w...

OBJECTIVES Psoriasis is a hyperproliferative chronic inflammatory skin disease of unknown etiology and ocular structures and visual pathways can also be affected during the course of this disease. Subclinical optic neuritis has previously been observed in psoriatic patients in visual evoked potential studies. This trial was designed to evaluate retinal sensitivity in patients with psoriasis vul...

Psoriasis vulgaris is a chronic, common skin disease, which affects the patient's quality of life to the highest degree. Several exogenous factors and endogenous hormonal changes may act as triggers for psoriasis. The skin possesses a true endocrine system, which is very important in multiple systemic diseases. A number of conditions are associated with psoriasis, and its severity can also be i...

BACKGROUND The association between psoriasis and the HLA antigens encoded by the Major Histocompatibility Complex (MHC) genomic region is well known, but the role of the HLA class II region in susceptibility to psoriasis is unclear. OBJECTIVE The purpose of this study is to map the psoriasis-susceptibility locus within the HLA class II region. METHODS Three hundred seventy five unrelated Ja...

BACKGROUND Traditional Chinese medicine (TCM) has a long history in the treatment of psoriasis vulgaris. We aimed to evaluate the clinical efficacy and safety of Chinese herbal Pulian ointment in treating psoriasis vulgaris of blood-heat syndrome. METHODS A multicenter, randomized, double-blind, placebo-controlled trial was conducted. Participants with psoriasis vulgaris of blood-heat syndrom...

REFERENCES: 1. McDonald HP, Garg AX, Haynes RB. Interventions to enhance patient adherence to medication prescriptions: scientific review. JAMA 2002; 288:2868–79. 2. Storm A, Andersen SE, Benfeldt E et al. One in 3 prescriptions are never redeemed: primary nonadherence in an outpatient clinic. J Am Acad Dermatol 2008; 59:27–33. 3. Elliott RA, Barber N, Horne R. Cost-effectiveness of adherence e...

PURPOSE Uveitis associated with psoriasis vulgaris is usually seen as an anterior segment inflammation, and it is very rare that the inflammation extends to the posterior segment. We herein report a case of severe panuveitis associated with psoriasis vulgaris presenting as retinal neovascularization, leading to vitreous hemorrhages that were successfully treated with infliximab (IFX). CASE RE...

Childhood psoriasis has a significant impact on the child ́s quality of life and those who cannot be managed with topical treatment should be considered for systemic treatment. The majority of systemic therapies used for childhood psoriasis are off-label drug therapies. Evidence-based studies on systemic treatment of childhood psoriasis are scarce, and treatment algorithms are generally based on...