OBJECTIVE To compare the bioavailability of single dose ibuprofen 200 mg and pseudoephedrine hydrochloride 30 mg administered alone or in combination as an oral suspension. METHODS This was a single-center, randomized, single-dose, open-label, 3-period, crossover study. After an overnight fast (≥10 h), 18 healthy male subjects received either ibuprofen 200 mg (reference-A), pseudoephedrine 30...

in this paper, the photocatalytic degradation of lidocaine hcl, an anesthetic was investigated inaqueous solution using cuo/zno as a photocatalyst. the degradation was studied under differentconditions including the amount of the photocatalyst, irradiation time, initial concentration of drug,ph of the system, initial concentration, addition of oxidant on the reaction rate and anion presence.the...

( ) ABSTRACT: The industrial and sanitary use of dithiocarbamates DTCs is on the rise, and the synthesis of new derivatives has increased the field of their application. Both positive and negative pharmacological and toxicological effects have been documented for DTCs. The development and application of new DTCs must be accompanied by the study of their toxicity, beginning with the performance ...

Background Oral histamine receptor–1 antagonists, such as fexofenadine, offer suboptimal relief of allergic rhinitis-associated nasal congestion. Combinations with oral sympathomimetics, such as pseudoephedrine, relieve congestion but produce side effects. Histamine receptor-3 antagonists, such as PF-03654764, reduce congestion in animals and have been proposed as novel therapeutics. Previous n...

We present a case of fetal tachycardia associated with maternal use of long-acting pseudoephedrine, an over-the-counter decongestant. No previous studies exist on pseudoephedrine or other over-the-counter decongestants and their effect on the fetal heart. The elevated fetal heart rate led to difficulty in interpreting a nonstress test. The normal human fetal heart rate at term is 110 to 160 bea...

A total of 466 healthy adults from four different regions of England entered a double-blind, randomised trial to test the effectiveness of an antihistamine (triprolidine) and a decongestant (pseudoephedrine), alone or in combination, in relieving symptoms of the common cold. During the study 199 subjects reported a total of 243 colds. Subjects recorded the severity of 12 symptoms during treatme...

A multicomponent pharmaceutical that contains loratadine, paracetamol, and pseudoephedrine was quantified using HPLC-PDA. The three analytes were well-separated in the dosage form on a C-18 column gradient mobile phase. quality by design strategy followed to achieve challenging separation. Screening optimization steps carried out investigate effect of many factors studied responses with minimum...

A spectrophotometric method was developed for simultaneous quantification of pseudoephedrine hydrochloride (PSE) triprolidine hydrochloride (TRI) using second derivative method (zero-crossing technique). The second derivative amplitudes of PSE and TRI were measured at 271 and 321 nm, respectively. The calibration curves were linear in the range of 200 to 1,000 g/ml for PSE and 10 to 50 g/ml for...