Let (M, g) be a pseudo-Riemannian manifold and Fλ(M) the space of densities of degree λ on M . We study the space D2 λ,μ(M) of second-order differential operators from Fλ(M) to Fμ(M). If (M, g) is conformally flat with signature p− q, then D2 λ,μ(M) is viewed as a module over the group of conformal transformations of M . We prove that, for almost all values of μ− λ, the O(p+1, q+1)-modules D2 λ...