نتایج جستجو برای: ps1 h

تعداد نتایج: 532947  

Journal: :The Journal of Cell Biology 2001
Philippe Cupers Mustapha Bentahir Katleen Craessaerts Isabelle Orlans Hugo Vanderstichele Paul Saftig Bart De Strooper Wim Annaert

We investigated the relationship between PS1 and gamma-secretase processing of amyloid precursor protein (APP) in primary cultures of neurons. Increasing the amount of APP at the cell surface or towards endosomes did not significantly affect PS1-dependent gamma-secretase cleavage, although little PS1 is present in those subcellular compartments. In contrast, almost no gamma-secretase processing...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
D E Kang S Soriano M P Frosch T Collins S Naruse S S Sisodia G Leibowitz F Levine E H Koo

Although an association between the product of the familial Alzheimer's disease (FAD) gene, presenilin 1 (PS1), and beta-catenin has been reported recently, the cellular consequences of this interaction are unknown. Here, we show that both the full length and the C-terminal fragment of wild-type or FAD mutant PS1 interact with beta-catenin from transfected cells and brains of transgenic mice, w...

Journal: :The Journal of biological chemistry 2001
R Killick C C Pollard A A Asuni A K Mudher J C Richardson H T Rupniak P W Sheppard I M Varndell J P Brion A I Levey O A Levy M Vestling R Cowburn S Lovestone B H Anderton

Presenilin 1 (PS1) regulates beta-catenin stability; however, published data regarding the direction of the effect are contradictory. We examined the effects of wild-type and mutant forms of PS1 on the membrane, cytoplasmic, nuclear, and signaling pools of endogenous and exogenous beta-catenin by immunofluorescence microscopy, subcellular fractionation, and in a transcription assay. We found th...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Malgorzata Marjanska Geoffrey L Curran Thomas M Wengenack Pierre-Gilles Henry Robin L Bliss Joseph F Poduslo Clifford R Jack Kâmil Ugurbil Michael Garwood

Currently no definitive biomarker of Alzheimer's disease (AD) is available, and this impedes both clinical diagnosis in humans and drug discovery in transgenic animal models. Proton magnetic resonance spectroscopy ((1)H MRS) provides a noninvasive way to investigate in vivo neurochemical abnormalities. Each observable metabolite can potentially provide information about unique in vivo pathologi...

2000
Melissa Handler Xudong Yang Jie Shen

PS1 is a major gene responsible for familial Alzheimer’s disease (FAD), and mutations in PS1 account for approximately 50% of early-onset FAD cases (Selkoe, 1998). Understanding the normal physiological functions of PS1 may shed light on the pathogenic mechanism of FAD-linked PS1 mutations. Identification of the PS1 homologue in C. elegans, sel-12, which facilitates signalling mediated by the N...

Journal: :Journal of neurophysiology 2005
David G Cook Xiaofan Li Sheree D Cherry Angela R Cantrell

Presenilins 1 and 2 (PS1 and PS2, respectively) play a critical role in mediating gamma-secretase cleavage of the amyloid precursor protein (APP). Numerous mutations in the presenilins are known to cause early-onset familial Alzheimer's disease (FAD). In addition, it is well established that PS1 deficiency leads to altered intracellular Ca(2+) homeostasis involving endoplasmic reticulum Ca(2+) ...

Journal: :Neuron 2008
Se Hoon Choi Karthikeyan Veeraraghavalu Orly Lazarov Seoan Marler Richard M. Ransohoff Jan Marino Ramirez Sangram S. Sisodia

Presenilin 1 (PS1) regulates environmental enrichment (EE)-mediated neural progenitor cell (NPC) proliferation and neurogenesis in the adult hippocampus. We now report that transgenic mice that ubiquitously express human PS1 variants linked to early-onset familial Alzheimer's disease (FAD) neither exhibit EE-induced proliferation, nor neuronal lineage commitment of NPCs. Remarkably, the prolife...

Journal: :Indian journal of experimental biology 2003
Shweta Bhatia Shivani Bhatia R C Dubey D K Maheshwari

Maximum colony growth inhibition was observed due to Pseudomonas PS2 (74%) as compared to PS1 (71%) on trypticase soy agar (TSM) plates after 5 days of incubation. Light and scanning electron microscopic examination showed hyphal coiling, vacuolation, coagulation and granulation of cytoplasm resulting in lysis of hyphae of M. phaseolina by pseudomonads. Cell free culture filtrates of strains PS...

Journal: :Neuron 1998
Satoshi Naruse Gopal Thinakaran Jin-Jun Luo John W Kusiak Taisuke Tomita Takeshi Iwatsubo Xiaozhong Qian David D Ginty Donald L Price David R Borchelt Philip C Wong Sangram S Sisodia

We have examined the trafficking and metabolism of the beta-amyloid precursor protein (APP), an APP homolog (APLP1), and TrkB in neurons that lack PS1. We report that PS1-deficient neurons fail to secrete Abeta, and that the rate of appearance of soluble APP derivatives in the conditioned medium is increased. Remarkably, carboxyl-terminal fragments (CTFs) derived from APP and APLP1 accumulate i...

2013
Kamran Honarnejad Christian KE Jung Sven Lammich Thomas Arzberger Hans Kretzschmar Jochen Herms

Mutations in presenilins (PS1 and PS2) account for the vast majority of early onset familial Alzheimer's disease cases. Beside the well investigated role of presenilins as the catalytic unit in γ-secretase complex, their involvement in regulation of intracellular calcium homeostasis has recently come into more focus of Alzheimer's disease research. Here we report that the overexpression of PS1 ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید