نتایج جستجو برای: prs

تعداد نتایج: 1779  

2013
F. Schubert J. Wendel A. Rügamer P. Neumaier F. Garzia P. Sommer G. Rohmer

The paper presents the hardware architecture of the Galileo PRS receiver developed within the BaSE project, and describes the core technologies required for using the Galileo PRS service. The approaches for increasing the robustness against radio frequency interference by using single sideband tracking techniques, adaptive notch filtering and pulse blanking are described. The potential of utili...

Journal: :Journal of immunology 2011
Javier de la Cruz Travis Kruger Christopher A Parks Robert L Silge Nicolai S C van Oers Immanuel F Luescher Adam G Schrum Diana Gil

The CD3ε cytoplasmic tail contains a conserved proline-rich sequence (PRS) that influences TCR-CD3 expression and signaling. Although the PRS can bind the SH3.1 domain of the cytosolic adapter Nck, whether the PRS is constitutively available for Nck binding or instead represents a cryptic motif that is exposed via conformational change upon TCR-CD3 engagement (CD3Δc) is currently unresolved. Fu...

2015
Rahul Mittal Kunal Patel Jeenu Mittal Brandon Chan Denise Yan M'hamed Grati Xue Zhong Liu

Phosphoribosylpyrophosphate synthetase 1 (PRPS1) codes for PRS-I enzyme that catalyzes the first step of nucleotide synthesis. PRPS1 gene mutations have been implicated in a number of human diseases. Recently, new mutations in PRPS1 have been identified that have been associated with novel phenotypes like diabetes insipidus expanding the spectrum of PRPS1-related diseases. The purpose of this r...

Journal: :Journal of immunology 2013
Aldo Borroto Irene Arellano Elaine P Dopfer Marek Prouza Miloslav Suchànek Manuel Fuentes Alberto Orfao Wolfgang W Schamel Balbino Alarcón

The adaptor protein Nck is inducibly recruited through its SH3.1 domain to a proline-rich sequence (PRS) in CD3ε after TCR engagement. However, experiments with a knockin mutant bearing an 8-aa replacement of the PRS have indicated that Nck binding to the TCR is constitutive, and that it promotes the degradation of the TCR in preselection double-positive (DP) CD4(+)CD8(+) thymocytes. To clarify...

2017
E. M. Venturini F. A. Drummond A. K. Hoshide A. C. Dibble L. B. Stack

Pollinator-dependent agriculture heavily relies upon a single pollinator-the honey bee. To diversify pollination strategies, growers are turning to alternatives. Densely planted reservoirs of pollen- and nectar-rich flowers (pollination reservoirs, hereafter "PRs") may improve pollination services provided by wild bees. Our focal agroecosystem, lowbush blueberry (Vaccinium angustifolium Aiton),...

2003
Wayne Wobcke

Although software agents are becoming more widely used, methodology for constructing agent programs is poorly understood. In this paper, we take a step towards specifying and proving correctness for a class of agent programs based on the PRS architecture, Georgeff and Lansky (1987), one of the most widely used in industrial settings. We view PRS as a simplified operating system, capable of runn...

2009
Soon Min Lee Min Soo Park Kook In Park Ran Namgung Chul Lee Jin Seong Lee Kyung A Lee Jong-Rak Choi

The Pierre Robin sequence (PRS) is the nonrandom association of micrognathia, cleft palate, and glossoptosis, leading to respiratory and feeding difficulties that appear neurogenic rather than mechanical in causation. Genetic determinants are thought to underlie this functional and morphological entity, based on the existence of Mendelian syndromes with PRS. Here, we demonstrate the association...

Journal: :Genetic epidemiology 2015
Wei Pan Yue-Ming Chen Peng Wei

To confirm associations with a large number of single nucleotide polymorphisms (SNPs), each with only a small effect size, as hypothesized in the polygenic theory for schizophrenia, the International Schizophrenia Consortium (2009, Nature 460:748-752) proposed a polygenic risk score (PRS) test and demonstrated its effectiveness when applied to psychiatric disorders. The basic idea of the PRS te...

Journal: :Molecular pharmacology 2013
Jordan Marrocco Jérôme Mairesse Domenico Bucci Luana Lionetto Giuseppe Battaglia Michol Consolazione Laura Ravasi Maurizio Simmaco Sara Morley-Fletcher Stefania Maccari Ferdinando Nicoletti

The use of classic antipsychotic drugs is limited by the occurrence of extrapyramidal motor symptoms, which are caused by dopamine (DA) receptor blockade in the neostriatum. We examined the impact of early-life stress on haloperidol-induced catalepsy using the rat model of prenatal restraint stress (PRS). Adult "PRS rats," i.e., the offspring of mothers exposed to restraint stress during pregna...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Doodipala Samba Reddy Ashwin Mohan

Progesterone plays a key role in ovarian cycle-related synaptic plasticity and neuronal excitability. Progesterone receptors (PRs), which mediate the cellular actions of progesterone, are expressed in the hippocampus and other limbic regions, but their functional significance remains unknown. Here, we report a novel role of PRs as crucial mediators in the development of epileptogenesis, which i...

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