Integrin-mediated adhesion is a critical regulator of cell migration. Here we demonstrate that integrin-mediated adhesion to high fibronectin concentrations induces a stop signal for cell migration by inhibiting cell polarization and protrusion. On fibronectin, the stop signal is generated through a5b1 integrin-mediated signaling to the Rho family of GTPases. Specifically, Cdc42 and Rac1 activa...

The aim of the current study was to examine matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) expression in patients with cervical disc herniation (CDH). A total of 127 specimens from CDH patients undergoing posterior spinal surgery were obtained for the case group, which was divided into three subgroups: lateral protrusion (N = 102), median protrusion (N =...

BACKGROUND Disorders of the cervical spine are often observed in patients with rheumatoid arthritis (RA). However, the best head position for RA patients with atlantoaxial subluxation in the perioperative period is unknown. This study investigated head position during general anesthesia for the patients with RA and proven atlantoaxial subluxation. METHODS During anesthesia of patients with RA...

This paper examines whether lip protrusion is affected by initial strengthening of rounded vowels in French. Three speakers produced sentences containing the vowels /i, e, ɛ, a, y, ø, œ, u, o, ɔ/ at the beginning of different prosodic constituents: Intonational Phrase (IP), Accentual Phrase (AP) and Word (W). Using video and Qualisys motion capture data, three parameters (lip protrusion, area/l...

Recent studies have demonstrated that actin filaments are not crucial for the short-term stability of tubular membrane protrusions originating from the cell surface. It has also been demonstrated that prominin nanodomains and curvature inducing I-BAR proteins could account for the stability of the membrane protrusion. Here we constructed an axisymmetric model of a membrane protrusion that exclu...

The ability to protrude the jaws during prey capture is a hallmark of teleost fishes, widely recognized as one of the most significant innovations in their diverse and mechanically complex skull. An elaborated jaw protrusion mechanism has independently evolved multiple times in bony fishes, and is a conspicuous feature in several of their most spectacular radiations, ultimately being found in a...

OBJECTIVE To analyze the pre-treatment cephalometric features in Saudi adults with bimaxillary protrusion and to develop cephalometric standards to clarify the overall presentation of this malocclusion for clinicians. METHODS A descriptive retrospective study was designed in which lateral cephalometric radiographs of 60 individuals with Class I skeletal and dental relationship and decreased i...

BACKGROUND AND PURPOSE Subjective determination of the posterior sclera flattening and optic nerve protrusion in MRI is challenging because of the 3D nature of the globe morphology. This study aims to develop and compare quantitative measures of globe flattening and optic nerve protrusion with subjective rating, and assess relationships with papilledema grade and intraocular and CSF pressures. ...

We propose a system that, using video information, segments the mouth region from a face image and then detects the protrusion of the tongue from inside the oral cavity. Initially, under the assumption that the mouth is closed, we detect both mouth corners. We use a set of specifically oriented Gabor filters for enhancing horizontal features corresponding to the shadow existing between the uppe...

Group II chaperonins found in archaea and in eukaryotic cytosol mediate protein folding without a GroES-like cofactor. The function of the cofactor is substituted by the helical protrusion at the tip of the apical domain, which forms a built-in lid on the central cavity. Although many studies on the change in lid conformation coupled to the binding and hydrolysis of nucleotides have been conduc...