PURPOSE With the aim of improving the results of treatment for esophageal carcinoma, we have investigated the efficacy and toxicity associated with the use of a 250-MeV proton beam for radical radiation therapy in esophageal carcinoma. EXPERIMENTAL DESIGN Thirty patients with esophageal carcinoma (superficial, n = 13; advanced, n = 17) had been treated with proton beam therapy alone or with p...

BACKGROUND High-LET ion irradiation is being more and more often used to control tumors in patients. Given that tumors are now considered as complex organs composed of multiple cell types that can influence radiosensitivity, we investigated the effects of proton and alpha particle irradiation on the possible radioprotective cross-talk between cancer and endothelial cells. MATERIALS AND METHOD...

Radiation tests of 32 lm thick hydrogenated amorphous silicon n–i–p diodes have been performed using a high-energy 24 GeV proton beam up to fluences of 2 · 10 protons/cm. The results are compared to irradiation of similar 1 lm and 32 lm thick n–i–p diodes using a proton beam of 405 keV at a fluence of 3 · 10 protons/cm. All samples exhibited a drop of the photoconductivity and an increase in th...

PURPOSE The aim of this study was to estimate the risk of brain microvessel radiation damage produced by exposure to proton irradiation. The microvessel endothelial populations and vessel topology to proton irradiation were quantified in the rat brain cortex and white matter following single and split dose schedules of protons using unbiased stereological techniques. This was a work in progress...

As part of the approval process for the use of scattered or uniform scanning proton therapy in National Cancer Institute (NCI)-sponsored clinical trials, the Radiological Physics Center (RPC) mandates irradiation of two RPC anthropomorphic proton phantoms (prostate and spine). The RPC evaluates these irradiations to ensure that they agree with the institutions' treatment plans within criteria o...

OBJECTIVE To examine ocular outcomes and survival after proton irradiation in patients with peripapillary and parapapillary melanomas ineligible for the Collaborative Ocular Melanoma Study. METHODS A total of 573 patients who received proton irradiation from January 4, 1985, through December 24, 1997, for tumors located within 1 disc diameter of the optic nerve, and therefore ineligible for t...

Silicone sponges were sutured to the sclera of owl monkeys to create an indentation which would simulate a tumor of the posterior segment of the eye. A tantalum clip inserted in the silicone sponge served as a marker for radiographic localization of the simulated tumors. The acute lesions obtained on the retina and choroid after moderately high doses of proton irradiation suggest that this meth...