Aurora kinase B, playing a vital, important role in mitosis, is frequently detected to be overexpressed in many cancer cell lines and various tumor tissues, including prostatic carcinoma. Given the essential function of Aurora kinase B in mitosis and its association with tumorigenesis, it might be a drug target for prostatic carcinoma treatment. In our study, short hairpin RNA targeting Aurora ...

OBJECTIVE Urothelial prostatic involvement (UPI) at the time of radical cystoprostatectomy (RCP) was found associated with worse survival outcomes by several previous reports. Our aim is to evaluate the impact of different levels of UPI on survival outcomes using a large series of male patients treated with RCP. METHODS Whole step section specimens from 995 male BCa patients were assessed for...

background in surgical pathology, atypical small acinar proliferation is commonly detected in prostate biopsies. most studies on atypical small acinar proliferation have examined morphological characteristics and the utility of immunohistochemical studies.however, these resources are not available to many pathology departments. we have found that examining additional sections is a simple and in...

Trans urethral resection of prostate (TURP) is the most frequently performed surgical treatment for patients diagnosed with benign prostate hyperplasia. This retrospective observational study was design to evaluate the occurrence and the characteristics of incidental prostate cancer (IPC), in patients underwent TURP for clinically benign disease. In histopathology of TURP specimens 14.9% showed...

We report a rare case of prostatic carcinoma associated with cystic degeneration. Cystic masses within the prostate are known. Benign cystic masses are more common and include congenital cysts of mullerian duct or mesonephric duct origin. Acquired cysts can be either retention cysts, parasitic or malignant in nature. Cysts accompanying prostatic carcinoma are moreover rare. The acute retention ...

Unilateral isolated Hypoglossal nerve palsy may result due to neoplasia, trauma, infections, autoimmune or vascular causes. We report a 52 year old male who presented with right hypoglossal nerve palsy and on evaluation was diagnosed to have prostatic malignancy with metastasis to the base of skull. Unilateral hypoglossal nerve palsy as the presenting feature of carcinoma prostate is rarely des...

BACKGROUND Xanthogranulomatous prostatitis is an unusual benign inflammatory process of prostate. Clinically it mimics prostatic carcinoma, requiring pathological examination for diagnosis. CASE PRESENTATION A 60-year-old patient presented with 6 months history of increasing difficulty in micturition. On digital rectal examination prostate was hard and nodular and estimated weight was 50-gram...

Male breast cancer is uncommon, accounting for less than 1% of all breast cancers. Carcinoma metastatic to the male breast is also unusual, with metastatic prostatic carcinoma being among the most common primary sites from which such tumours derive. Metastatic prostatic cancer and primary breast cancer may be histologically indistinguishable without immunohistochemistry because both often infil...

High grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostatic carcinoma. PIN has a high predictive value as a marker for carcinoma, and its identification in biopsy specimens warrants repeat biopsy for concurrent or subsequent carcinoma. The only methods of detection are biopsy and transurethral resection; PIN does not greatly raise the concentration of serum pr...

Prostatic ductal adenocarcinomas may arise either in large primary periurethral prostatic ducts or in the peripheral prostatic ducts. Ductal adenocarcinomas are composed of tall columnar cells arranged in cribriform, papillary, solid, single glands, and PIN-like patterns. Other than the prostatic intraepithelial neoplasia (PIN)-like ductal pattern, which behaves like Gleason pattern 3, ductal a...