Objective: To compare prostatic diseases like BPH and Prostatic cancer by estimating the levels of serum Prostatic Acid phosphatase (PAP) and total PSA levels. PSA is an extremely useful tumour marker in prostatic diseases. In normal cases PSA ranges from 0-4ng/ml. Values between 4-10ng/ml are seen in cases of BPH and above levels are seen in prostatic cancer. Normal serum PAP ranges from 0-5 K...

The goal of this study was to determine if patients with stage D0-3 prostatic adenocarcinoma have detectable hematogenous micrometastasis. Polymerase chain reaction amplification of prostate-specific antigen mRNA, which is exclusively expressed by prostatic epithelial cells, was used to detect circulating prostatic cells. Peripheral venous blood was obtained from 17 control and 12 prostate canc...

Prostatic involvement by urothelial carcinoma in patients with bladder cancer is a frequent finding and their prognostic significance and implication for the management of these patients has been the subject of study for many years. In one of the largest series of radical cystoprostatectomy with 995 patients with bladder cancer, Moschini M et al have shown that prostatic involvement by urotheli...

The reported detection rate of prostate cancer, lesions suspicious for cancer, and prostatic intraepithelial neoplasia (PIN) in needle biopsies is highly variable. In part, technical factors, including the quality of the biopsies, the tissue processing, and histopathological reporting, may account for these differences. It has been thought that standardisation of tissue processing might reduce ...

Progression of prostatic cancer from nonmetastatic to high metastatic ability may involve the loss of a metastasis suppressor gene. To test this possibility, nonmetastatic and highly metastatic Dunning rat prostatic cancer cells were fused. Hybrid clones were isolated which conserved the chromosomes from their parental cells. When these hybrids were injected into animals, none developed distant...

Aims: Benign prostatic hyperplasia and adenocarcinoma are common diseases that account for considerable morbidity and mortality of ageing population. In cancer related deaths in men, the prostatic cancer is the second most common to lung cancer. Purpose of this study is to analyze various clinicopathological features in benign and malignant prostatic lesions, to correlate of benign and malignan...

MLH1 immunoreactivity in prostatic adenocarcinoma. The increased MLH1 expression in the precursor lesion HGPIN suggests a role of MLH1 in prostatic carcinogenesis. However, its expression may not be related to the aggressiveness of prostatic cancer, because the intensity of immunoreactivity is similar in both intermediate and high-grade prostatic adenocarcinoma. Lastly, we have demonstrated the...

Lung cancer metastases to the prostate are uncommon, and are usually found incidentally during autopsy. This case report describes a 77-year-old man with a large cell neuroendocrine carcinoma (LCNEC) of the lung and metastases from this primary cancer in the prostate. During the follow-up after the chemotherapy performed for pulmonary LCNEC, pelvic computed tomography revealed a prostatic tumor...

Background: Prostatic carcinoma is one of the most important causes of mortality in elderly men mainly because of the late detection despite of the fact that it is a potentially curable disease. Fine needle aspiration cytology (FNAC) is an easy to perform outpatient procedure requiring no expensive equipment or anesthesia. Objectives: The present study was carried out in an attempt to evaluate ...

IN 1941 research in prostatic cancer received great impetus from the discovery by Huggins and his associates 1 that remarkable regression occurred clinically in the primary neoplasm and its metastases after castration or administration of estrogen. These findings were subsequently verified by others.2 Unfortunately, the gratifying improvement manifested by most patients treated in this manner h...