PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition is an effective therapy to reduce low-density lipoprotein cholesterol and cardiovascular events. A recent study shows that 1 or 2 doses of inclisiran, a long-acting synthetic small-interfering RNA that selectively targets hepatic PCSK9, causes a sustained reduction of plasma low-density lipoprotein cholesterol for ≤6 months. Pendi...
