l As described in the preceding communication, either propranolol hydrochloride or hydrochlorothiazide were randomly allocated in a doubleblind manner to 683 patlents with Initial diastolic BP in the range of 95 to 114 mm Hg. Of this number, 394 entered the long-term treatment phase. During the subsequent 12 months of long-term treatment, hydrochlorothiazlde was more effective than propranolol ...

Neuroblastoma (NB) is a pediatric tumor of the sympathetic nervous system, which is often associated with elevated catecholamines. More than half of patients with metastatic NB relapse and survival is extremely poor with current therapies. In a high-throughput screen of FDA-approved drugs we identified anti-NB activity for the nonselective β-adrenergic receptor antagonist propranolol hydrochlor...

The objective of the study was to develop a suitable trans-dermal delivery system for propranolol hydrochloride (PPL) via employing chitosan as a film former. Drug concentration uniformity, thickness, moisture uptake capacity and skin bioadhesion of the films were characterized. The effects of chitosan and PPL concentration and different penetration enhancers on the release and permeation profi...

Propranolol, a widely used beta-blocker, inhibits the hydrolysis reaction of enzyme cholinesterase. Measurements of the difference in rate of hydrolysis rate between uninhibited and inhibited reactions allow the development of a kinetic method for its determination. Both systems, enzyme–substrate–chromogen and enzyme–substrate–chromogen–inhibitor, were characterized through biochemical kinetic ...

The objective of the current study was to determine tablet content and perform dissolution test of expired tablets and tablets which expiry date has not exceeded. The analyzed tablets contained metoprolol tartrate (50 mg) and propranolol hydrochloride (10 mg), respectively. Content determination was performed using spectrophotometric method with UV detection; the percent of dissolved substance ...

I. OLARIU, G. CONEAC, L. VLAIA, V. VLAIA, D. F. ANGHEL, C. ILIE, C. POPOIU, D. LUPULEASA ”Victor Babeş” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eftimie Murgu Square 1, 300041, Timişoara, Romania “Victor Babeş” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Organic Chemistry, Eftimie Murgu Square 1, 300041, Timiş...

The model system propranolol hydrochloride (PROP-HCl)/AmberliteTM was studied in terms of equilibrium concentrations and amount drug bound to the ion exchanger, and compared to the system potassium chloride (KCl)/AmberliteTM. It was found that both the affinity and exchange capacity of AmberliteTM for PROP-H + ions is higher than for K + . Specific heat effects of the exchange reaction measured...