The kinetics of propranolol enantiomers are stereoselective when high doses of the racemic drug are given po. To document whether the dose and/or the route of administration determines the stereoselective kinetics of propranolol enantiomers, conscious rabbits received 40, 80, or 120 mg/kg po or 0.5 or 10 mg/kg iv doses of racemic propranolol, and serial blood samples were obtained to assay prop...

1. Carp, when subjected to air stress in vivo, developed a hypoxaemia associated with an acidosis due to elevation of PCO2 and arterial lactate content. Adrenaline and noradrenaline levels rose markedly, and the mean corpuscular haemoglobin concentration (MCHC in mmol Hb l-1 red blood cells) decreased, indicating swelling of the erythrocytes. 2. No effect of adrenaline could be observed in vitr...

1. Propranolol, a beta-blocker, inhibited or stimulated ryanodine binding to both the membrane-bound and purified ryanodine receptor (RyR) depending on the assay conditions. At high NaCl concentrations, propranolol increased the number of ryanodine-binding sites (Bmax) with no effect on the binding affinity. In the presence of 0.2 M NaCl, ryanodine binding was inhibited by propranolol. Half-max...

1 Characterization of the ,B-adrenoceptors mediating inhibition of gastric acid secretion in the conscious Heidenhain pouch dog has been investigated by determination of the effects of propranolol, (+)-propranolol, practolol and H35/25 on salbutamol and isoprenaline-induced inhibition of gastric acid secretion. 2 The gastric antisecretory effect of salbutamol was significantly blocked by propra...

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The purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. Propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier ...

The relationship between plasma propranolol concentration and relief of essential tremor was examined in 11 patients during treatment with oral racemic propranolol in doses of 30 to 640 mg/day. Although propranolol decreased tremor in all 11 patients, the degree of improvement varied widely in individuals (mean 51%, range 25--90%), and was not related directly occurred at plasma propranolol con...

Cerebral autoregulation and vasomotor responsiveness to carbon dioxide were measured quantitatively in normal baboons before and after intravertebral or intravenous infusion of the beta-adrenergic blocking agent, propranolol hydrochloride (Inderal®). Continuous measurements were made of cerebral blood flow (CBF: measured as bilateral internal jugular venous outflow using an electromagnetic flow...

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

The binding affinities of racemic derivatives of propranolol to ƒÀ-adrenoceptors were examined by means of radioligand binding assay to determine whether racemic propranolol shows biphasic binding to ,ƒÀ-adrenoceptors in a displacement experiment. Rat brain was used and the ƒÀadrenoceptor binding assay was carried out with 3H-dihydroalprenolol as the radioligand. A higher affinity of l-proprano...