Acute scrotal abscess is an extremely rare condition in neonates and may mimic testicular torsion. Most of these abscesses have reportedly been due to Staphylococcus and Salmonella spp. infections. We herein report a unilateral acute scrotal abscess in a preterm infant born at 26 weeks in whom Propionibacterium acnes was isolated from the collected scrotal fluid culture. To our knowledge, this ...

Acne represents a chronic inflammatory disease, very frequent in adult persons and with a big impact on the patient’s quality of life. Propionibacterium acnes (P acnes) is involved in acne pathogenesis and its eradication requires treatment with antibacterial substances, especially antibiotics. The use of antibiotics in acne was associated with the development of P acnes resistance to antibioti...

In the US annually there are 600,000 joint prostheses and 2,000,000 fracture-fixation devices surgically implanted with an average rate of infection of 2% and 5% respectively for primary insertion. [1]. Infected orthopedic hardware is most successfully cured by a combination of prolonged antibiotics and surgical replacement, sometimes involving a 2-step operative procedure that incurs increased...

Propionibacterium acnes is the cause of inflammation in acne vulgaris and has been shown to produce potent neutrophil chemoattractants. Different strain of P. acnes that were sensitive or resistant to ampicillin, erythromycin, minocycline, and tetracycline were grown in the presence of subminimal inhibitory concentrations of the drugs, and their culture supernatants were assayed for neutrophil ...

Acne vulgaris is a multifactorial disease of as yet incompletely elucidated etiology and pathogenesis. The following have been identified as the most significant factors: follicular hyperkeratosis, increased sebum secretion, Propionibacterium (P.) acnes, and inflammation. Increased sebum production and follicular hyperkeratosis result in the development of microcomedones, and changes in follicu...

scratched the fungal colonies around the incision. The organisms adhered to the tip of the injector nozzle when IOL was inserted, resulting in the intraocular infection. Slit lamp biomicroscopy showed cyclitic membranes around the superior corneal incision linking to the surface of IOL, which correspond to the pathogenic mechanism. Interestingly, the presentation of intraocular inflammation in ...

The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes. RoxP is uniquely produced by the predominant skin bacterium P. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture...

A designed peptide named LZ1 with 15 amino acid residues containing strong antimicrobial activity against bacteria pathogens of acne vulgaris including Propionibacterium acnes, Staphylococcus epidermidis and S. aureus. Especially, it exerted strong anti-P. acnes ability. The minimal inhibitory concentration against three strains of P. acnes was only 0.6 µg/ml, which is 4 times lower than that o...