BACKGROUND Prostate cancer is a disease associated with aging. Also commonly associated with increasing age is a shift in the prooxidant-antioxidant balance of many tissues toward a more oxidative state, i.e., increased oxidative stress. We hypothesize that androgen exposure, which has long been associated with the development of prostate cancer, may be a means by which the prooxidant-antioxida...

Background: Fullerenes and metallofullerenes can be considered promising nanopharmaceuticals themselves as a basis for chemical modification. As reactive oxygen species homeostasis plays vital role in cells, the study of their effect on genes involved oxidative stress anti-inflammatory responses are particular importance. Methods: Human fetal lung fibroblasts were incubated with aqueous dispers...

BACKGROUND Oxidative stress, resulting from an antioxidant/prooxidant imbalance, seems to be crucial in atherogenesis. Recent evidence has emerged, however, of a surprisingly high content of low-molecular-weight antioxidants in human atherosclerotic plaques, although other antioxidant systems have not been investigated in these lesions. METHODS AND RESULTS We studied glutathione-related antio...

Knowledge of lead's capacity to disrupt the prooxidant/antioxidant balance within mammalian tissues suggests that definitive therapy for chronic lead poisoning should encompass both chelating and antioxidant actions. The dithiol meso-2,3-Dimercaptosuccinic Acid (DMSA) is the first orally administered metal chelating agent to receive U.S. Food and Drug Administration (FDA) approval for the treat...

Aim. To study the state of prooxidant-antioxidant blood system in children with community-acquired pneumonia. Material and methods. A 100 aged 10 to 17 years pneumonia was carried out. Results. It found that is accompanied by a decrease antioxidant protection significant increase lipoperoxidation processes, depending on type Conclusions. The development oxidative stress, an pro-oxidants factors...

Nutraceutical compounds show antioxidant and prooxidant properties under stress conditions like cancer, diabetes, and other diseases. The objective of this study is to find the dichotomic behavior of caffeine, curcumin, and naringenin on DNA of diabetic and normal subjects in the presence and absence of copper, hydrogen peroxide, and complex of copper-hydrogen peroxide. Hydrogen peroxide releas...