Torsade de pointes (TdP) is increasingly recognized as a complication of drug therapy. The most common cause of drug-induced QT prolongation is inhibition of the rapidly activating component of the delayed potassium current (IKr). Moxifloxacin, a widely used fluoroquinolone, is a weak IKr inhibitor and has been associated with QT prolongation. We report a case of marked QT prolongation (618 ms)...

Electrical stimulation of the carotid sinus nerves was applied during diagnostic catheterization of two patients who had coronary artery disease. The immediate reflex prolongation of the atrioventricular (AV) interval was due to prolongation of the AH interval only and was roughly parallel to the reflex RR interval prolongation evoked without atrial pacing. After cholinergic block, the reduced ...

QT interval prolongation is associated with an increased risk of ventricular arrhythmia in various conditions. Cardiac electrophysiologic abnormalities including QT interval prolongation are well documented in patients with advanced liver cirrhosis. We report two cases of patients with QT interval prolongation on preoperative electrocardiography who exhibited repetitive ventricular arrhythmias ...

Background: Although various anesthetic techniques can be used in different kinds of surgeries, spinal anesthesia has received considerable attention for the lower abdomen and lower extremities surgeries and cesarean section. This study aimed at comparing the effect of adding epinephrine 1:1000 and 1:10000 to lidocaine and fentanyl in spinal anesthesia on the prolongation of paralysis, analgesi...