Abstract We describe a multiphysics model of the collagen structure cornea undergoing progressive localized reduction stiffness, preluding to development ectasia and keratoconus. The architecture stromal is assumed follow simplified two-family proposed in Pandolfi et al. (A microstructural cross-link interaction between fibrils human cornea. Philos Trans R Soc A 377:20180079, 2019), where mecha...

Midstromal implant of an isolated Bowman layer graft is a new approach to reduce ectasia in eyes with advanced keratoconus. The procedure should postpone penetrating or deep anterior lamellar keratoplasty. Ten eyes of 9 patients with progressive, advanced keratoconus and contact lens intolerance underwent the procedure with no intraoperative adverse events. Throughout the study period, we obser...

The development of corneal ectasia has been recognized as a complication after LASIK since the first case report from Seiler and Quurke in the late 1990s. The clinical picture of iatrogenic corneal ectasia resembles that of progressive keratoconus with reduced corneal biomechanical strength, increasing central corneal steepness, irregular refractive errors, and decreasing visual acuity. Since t...

PURPOSE Brittle cornea syndrome 1 (BCS1) is a rare recessive condition characterized by extreme thinning of the cornea and sclera, caused by mutations in ZNF469. Keratoconus is a relatively common disease characterized by progressive thinning and ectasia of the cornea. The etiology of keratoconus is complex and not yet understood, but rare ZNF469 variants have recently been associated with dise...

PURPOSE Our main purpose was to compare safety and efficacy in the treatment of progressive keratoconus with "epithelium-on" and "epithelium-off" corneal collagen cross-linking (CXL). Our secondary purpose was to evaluate efficacy of CXL when hypotonic 0.5% riboflavin is used as photosensitizer. METHODS One eye of 20 patients with bilateral progressive keratoconus was randomly treated for "ep...

BACKGROUND Keratoconus typically presents in the teenage years and is more advanced in younger patients when compared with adults. In the present study, we aimed to assess the safety and efficacy of accelerated transepithelial corneal collagen cross-linking (ATE-CXL) in children with progressive keratoconus. METHODS In this retrospective consecutive study, 18 eyes were enrolled from 17 pediat...

Keratoconus and other corneal conditions associated with progressive stromal thinning including keratectasia after laser-assisted in situ keratomileusis (LASIK) and pellucid marginal degeneration represent therapeutic challenges. Until recently, available therapies including contact lenses, epikeratoplasty, intrastromal corneal rings, and corneal transplantation targeted, in principle, the abno...

PURPOSE To analyze the safety and efficacy of standard corneal collagen cross-linking (CXL) in advanced cases of progressive keratoconus after 4 years of follow-up. METHODS A retrospective case series of patients with advanced progressive keratoconus (stages 3 and 4 of Amsler-Krumeich classification) underwent standard CXL treatment. The parameters examined were changes in uncorrected visual ...