Progressive visual failure as the presenting feature of multiple sclerosis is described in five patients. The clinical features did not permit a distinction from visual loss due to compression. The finding of oligoclonal bands in the CSF at presentation is a useful pointer to the diagnosis, but is not specific and full investigation to exclude treatable causes of visual loss is essential.

Railways are one of the largest transportation networks in world. One key subgrade problems railway track is associated with progressive shear failure (PSF). To-date, limited number studies have addressed mechanism PSF, especially extending mechanics unsaturated soils. In this paper, PSF studied aid computer program that was developed using a Visual Basic AutoCAD, Mohr-Coulomb criteria within s...

Adenine phosphoribosyl-transferase (APRT) is the key enzyme that transforms adenine into adenylate monophosphate (AMP). In case of APRT deficiency, xanthine oxidase rapidly oxidizes adenine into 2,8-dihydroxyadenine (2,8-DHA), which is then eliminated by the kidneys through tubular secretion. 2,8-DHA is insoluble at a physiologic range of pH; therefore, it can easily precipitate in the urine. A...

because it is not possible to recognize the mechanism of cantilever failure in field studies, this type of common failure in riverbanks is investigated in the laboratory. for this purpose, two samples of susceptible soil that forms an overhanging block in riverbanks are used for physical model tests to determine their physical, chemical and mechanical characteristics. soil blocks of different d...

  Multiple aorto-cardiac cavity communications is very rare but important complication of prosthetic aortic valve endocarditis. The case below illustrates multiple aorto-cardiac cavity fistula formation following prostethic aortic valve endocarditis presented with slowly progressive symptoms of heart failure. A brief review of surgical reconstruction and the existing literature are presented, i...

This paper is concerned with a progressive failure analysis methodology for fiber reinforced composite laminates combining various analytical models designed for investigating failure mechanisms at different length scales. The methodology here employs a fundamental mechanism based approach to predict failure or damage initiation with strong coupling between the multiple length scales. The discr...

diffuse hepatic inltration is an unusual form of hodgkin's disease (hd). its manifestation as progressive hepatitis or with hepatic failure is even rarer and can be difcult to diagnose. we aim to describe an unusual case of liver failure due to hd. a middle-aged woman with a 10 month history of daily febrile episodes, constitutional symptoms and strikingly high levels of serum ferritin was admi...