Introduction: In this research, [166Ho]Holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed. Methods: 166</s...

Introduction: Optimized production and quality control of 68Ga-DOTATATE as an efficient and preferable PET radiotracer for somatostatin receptor imaging in neuroendocrine tumors is of great interest. In this study effort has been made to present a fast, efficient, cost-effective and facile protocol for 68Ga-DOTATATE productions for clinical trials. Methods:68Ga...

Breast cancer radioimmunoscintigraphy targeting HER2/neu expression is a growing fieldof work in nuclear medicine research. In this study, trastuzumab was successively labeledwith [67Ga] GaCl3 after conjugation with DOTA-NHS-ester.The conjugates were purified by molecular filtration, the average number ofDOTA conjugated per mAb was calculated and total concentration was determined byspectrophot...

Background: 66Ga (t1/2=9.49 h, β+: 4.153 MeV, γ: 511, 834, 1039, 2752 keV) has a wide range of applications in different fields of medical sciences. Production of 66Ga became one of our main interests, according to its increasing applications in nuclear medicine, particularly in PET imaging. Materials and Methods: 66 Zn (p,n)66Ga reaction was determined as the best choice for the production of ...

Cell Formation (CF) is the initial step in the configuration of cell assembling frameworks. This paper proposes a new mathematical model for the CF problem considering aspects of production planning, namely inventory, backorder, and subcontracting. In this paper, for the first time, backorder is considered in cell formation problem. The main objective is to minimize the total fixed and variable...

Steady state and dynamic fermentations of baker's yeast in molasses based media were analyzed in a laboratory scale bioreactor. Sugar and biomass balances together with the Monod biokinetics were used to develop the process model. Parameters of the model were obtained using collected experimental data. Model predicted open loop responses to step changes in feed concentration as well as dilu...

The use of [18F]-2-FDG has been increasing in recent years. This agent was originally used for evaluation of CNS glucose uptake and pathologic conditions by positron emission tomography (PET). In view of increasing demand for this agent, its production has been started at cyclotron dept., Nuclear research center for agriculture & Medicine-Karaj Iran (NRCAM). In this paper, [18F]-FDG synth...