Recovery of metabolites from fermentation broth by solvent extraction can be used to optimize fermentation processes. End-product reutilization, low product concentration, large volumes of fermentation broth and the requirements for large bioreactors, in addition to the high cost largely contributed to the decline in fermentative 2, 3-butanediol production. Extraction can ...

the aim of this investigation was to improve the storage stability and survival rate of intravesical bcg product, manufactured with an attenuated strain of mycobacterium bovis (pasteur strain 1173p2 of bcg) in the presence of sodium glutamate. formulations with various concentrations of trehalose (a known protectant) were developed as liquid and lyophilized forms. formulations were evaluated by...

new product development (npd) is one of the key factors for achieving competitive advantage and maintaining firm growth. therefore, given the importance of this type of projects, this paper is an endeavor to make these projects more successful by effectively managing their risks in the conceptual design phase of new product development. for this purpose, a multi-objective model, with three obje...