The aim of many genetic studies is to locate the genomic regions (called quantitative trait loci, QTL) that contribute to variation in a quantitative trait (such as body weight). Confidence intervals for the locations of QTL are particularly important for the design of further experiments to identify the gene or genes responsible for the effect. Likelihood support intervals are the most widely ...

A new method is developed for estimating rates of somatic mutation in vivo. The stop-enhanced green fluorescent protein (EGFP) transgenic mouse carries multiple copies of an EGFP gene with a premature stop codon. The gene can revert to a functional form via point mutations. Mice treated with a potent mutagen, N-ethyl-N-nitrosourea (ENU), and mice treated with a vehicle alone are assayed for mut...

Surles and Padgett [15] introduced two-parameter Burr Type X distribution, which can be described as a generalized Rayleigh distribution. In this paper we consider the estimation of the stress-strength parameter R = P [Y < X], when X and Y are both three-parameter generalized Rayleigh distribution with the same scale and locations parameters but different shape parameters. It is assumed that th...

The objective of this article is to conduct a full study on the failure times items when subjected progressive-stress accelerated life test. These follow Modified Kies exponential distribution. We performed experiments under type-II censoring scheme with binomial removal. stress design has two ways be applied either simple ramp-stress test or multiple level acceleration. made comparison between...

Process capability indices (PCIs) have been widely used in industries for assessing the capability of manufacturing processes. Castagliola and Castellanos (Quality Technology and Quantitative Management 2005, 2(2):201–220), viewing that there were no clear links between the definition of the existing multivariate PCIs and theoretical proportion of nonconforming product items, defined a bivariat...

This paper discusses statistical inference and optimal design of constant-stress accelerated life testing for the Chen distribution under progressive Type-II censoring. The scale parameter is assumed to be a logarithmic linear function stress level. maximum likelihood estimates parameters are obtained. Then, observed Fisher information matrix derived utilized construct asymptotic confidence int...

This study deals with simple Constant Stress Partially Accelerated life test (CSPALT) using type-I censoring. The lifetime distribution of the test item is assumed to follow Gompertz distribution. The Maximum Likelihood (ML) Estimation is used to estimate the distribution parameters and acceleration factor. Asymptotic confidence interval estimates of the model parameters are also evaluated by u...

With increasing emphasis on quality in industry, semiconductor devices are now made more reliable and fewer failures are observed in a short product development cycle. In this circumstance, assessing product reliability based on failure-times becomes very difficult. In the study of hot-carrier-induced degradation, measurements of transconductance loss could be recorded over time and these measu...