in this paper, the photocatalytic degradation of lidocaine hcl, an anesthetic was investigated inaqueous solution using cuo/zno as a photocatalyst. the degradation was studied under differentconditions including the amount of the photocatalyst, irradiation time, initial concentration of drug,ph of the system, initial concentration, addition of oxidant on the reaction rate and anion presence.the...

A73-year-old man with mild coronary artery disease and a dilated cardiomyopathy presented to the emergency room with a hemodynamically stable wide-QRS tachycardia. His 12-lead ECG revealed episodes of ventriculoatrial block, and a diagnosis of ventricular tachycardia (VT) was made (Figure 1). Intravenous procainamide restored sinus rhythm. Tachycardia recurred, and a second bolus of intravenous...

We studied the role of the anticholinergic properties of disopyramide and quinidine in mediating the electrophysiological effects of these agents on isolated cardiac tissue. In right atria, disopyramide, quinidine, and procainamide administered alone elicited negative chronotropic responses. However, after cholinergic stimulation with physostigmine (1 X 10" M), disopyramide and quinidine produc...

Secreted Wingless type (Wnt) ligands have previously been shown to be involved in tumor developmental processes and oncogenesis. Aberrant promoter methylation of Wnt inhibitory factor-1 (WIF-1) is a fundamental mechanism of epigenetic silencing in human cancers. Procaine, a local anesthetic drug, and procainamide, a drug for the treatment of cardiac arrhythmias, have been reported as inhibitors...

We studied the role of the anticholinergic properties of disopyramide and quinidine in mediating the electrophysiological effects of these agents on isolated cardiac tissue. In right atria, disopyramide, quinidine, and procainamide administered alone elicited negative chronotropic responses. However, after cholinergic stimulation with physostigmine (1 X 10" M), disopyramide and quinidine produc...

-1. The effects of three class I antiarrhythmic drugs procainamide (class IA), tocainide (class IB) and lorcainide (class 1C) on microsomal Na+-K+-ATPase activity were compared with those of ouabain in guinea pig heart preparations. 2. All three antiarrhythmic drugs exhibited concentration-dependent inhibitory actions on the enzyme activity in a fashion similar to that of ouabain. 3. The rank o...

This study delineates the time course of procainamide accumulation in myocardium after bolus administration and its relationship to regional myocardial blood flow. The left circumflex coronary artery was ligated in 28 open-chest dogs. This was followed 40 minutes later by injection into the left atrium of labeled microspheres. C-labeled procainamide, 1.5 mg/kg, was then administered as a single...

OBJECTIVES Acute atrial fibrillation and flutter are very common arrhythmias seen in emergency department (ED) patients, but there is no consensus for their optimal management. The objective of this study was to examine the efficacy and safety of intravenous (IV) procainamide for acute atrial fibrillation or flutter. METHODS This health records review included a consecutive cohort of ED patie...

We compared the relationship between plasma levels of procainamide and suppression or prevention of various forms of ventricular arrhythmias in 18 patients, six of whom had premature ventricular complexes (PVCs) during acute myocardial infarction (AMI), six of whom had PVCs in the setting of stable chronic ischemic heart disease (CIHD), and six of whom had recurrent symptomatic ventricular tach...

BACKGROUND Autonomic modulation, especially increased sympathetic activity may play a role in the genesis of ventricular arrhythmias. The purpose of this study was to determine whether beta-sympathetic stimulation with isoproterenol would alter sustained ventricular tachycardia (VT) circuits similarly during the drug-free and antiarrhythmic drug-treated states. METHODS AND RESULTS Twenty-five...