Inhaltsverzeichnis 1. Einleitung 1 2. PRIMA 2 2.

In this paper we present PRIMA: a new model tailored to symbolic music that detects the meter and the first downbeat position of a piece. Given onset data, the metrical structure of a piece is interpreted using the Inner Metric Analysis (IMA) model. IMA identifies the strong and weak metrical positions in a piece by performing a periodicity analysis, resulting in a weight profile for the entire...

Mutations in wild-type p53 (wtp53) protein lead to loss of its tumor suppressor function in breast cancer cells, facilitating uncontrolled tumor growth. Consequently, procedures to repair defective p53 functions in tumor cells are being actively pursued. We sought to determine whether expression of wtp53 protein, or conversion of endogenous mutant p53 (mtp53) into a functional p53 protein with ...

OBJECTIVE Cigarette smoking is the main risk factor for bladder cancer development. Among the mediators of this effect of smoking is nuclear factor-kappa B. Curcumin suppresses cellular transformation by downregulating the activity of nuclear factor-kappa B. Prima-1 is a compound that induces apoptosis in human tumor cells, restoring the function of mutant p53. Our study aimed to evaluate the e...

We present a new passive model reduction algorithm based on the Laguerre expansion of the time response of interconnect networks. We derive expressions for the Laguerre coefficient matrices that minimize a weighted square of the approximation error, and show how these matrices can be computed efficiently using Krylov subspace methods. We discuss the connections between our method and other meth...

BACKGROUND AND AIM OF THE STUDY The study aim was to compare the crosslink stability and calcification behavior of porcine tissue (cusp and wall), treated with a new antimineralization process (ADAPT) with that of commercially prepared Freestyle and Prima Plus bioprosthetic tissues. METHODS Porcine aortic roots were divided into two groups: (i) tissue zero pressure-fixed with 0.625% glutarald...

Acetylcholinesterase (AChE) is responsible for the hydrolysis of the neurotransmitter, acetylcholine, in the nervous system. The functional localization and oligomerization of AChE T variant are depending primarily on the association of their anchoring partners, either collagen tail (ColQ) or proline-rich membrane anchor (PRiMA). Complexes with ColQ represent the asymmetric forms (A(12)) in mus...

The perl language is a powerful tool for creation of portable programs on a wide range of platforms. Support of the graphic user interface is not included in perl, and is provided by several stand-alone graphical toolkits. The most popular modules are Perl-Tk and Wx, based on multi-platform libraries, correspondingly Tcl-Tk and wxWindows, both written in C. The toolkit Prima was written to prov...