The effect of delta9-tetrahydrocannabinol (THC), the major psycho-active component of marijuana, in human prostate cancer cells PC-3 was investigated. THC caused apoptosis in a dose-dependent manner. Morphological and biochemical changes induced by THC in prostate PC-3 cells shared the characteristics of an apoptotic phenomenon. First, loss of plasma membrane asymmetry determined by fluorescent...

background: although the effectiveness of ginger as an antioxidant agent has been exploited, little human research has been conducted on its activity on male reproductive functions. objective: this study was designed to investigate the effects of ginger (zingiber officinale) on sperm dna fragmentation (sdf) in infertile men. materials and methods: this randomized double-blind, placebo-controlle...

Earlier studies have shown that the d120 mutant of herpes simplex virus 1, which lacks both copies of the alpha4 gene, induces apoptosis in all cell lines tested. In some cell lines d120-induced apoptosis, manifested by the release of cytochrome c, activation of caspase 3, and fragmentation of cellular DNA, is blocked by the overexpression of Bcl-2. In these cells viral protein kinase U(S)3 del...

Human beings are prone to celebrate festivals to intellectualize the principle of contingency that characterizes the world wherein they dwell on. Basically, the present paper explores the sociological and anthropological roots of Event-Management as an instrument to prevent the social fragmentation in context of disturbance and uncertainness. We focus Charisma, ethno-genesis, hegemony, heroism ...

In the present work, we show that chick embryo Schwann cells die by apoptosis both during normal development and after axonal degeneration induced by neurotoxin treatment. Schwann cell apoptosis during development takes place during a period roughly coincidental with normally occurring motoneuron death. Administration of NMDA to chick embryos on embryonic day 7 induces extensive excitotoxic mot...

Background: Infertility is estimated to affect up to 15% of couples of reproductive age, and male factors contribute to 50% of these cases. Globozoospermia syndrome is a severe form of teratozoospermia, with an incidence of less than 0.1%. It is characterized by round sperm head. The most prominent feature of globozoospermia is the malformation of the acrosome, which is totally absent in the to...

Internet Protocols are utilized to empower the communication between computing devices in computer networks. IPv6 offers additional address space and more noteworthy security than IPv4. The progress from IPv4 has been finished through three primary change systems: dual-stack, tunneling, translation. relies upon similarity with enormous introduced base of nodes routers just as keeping up network...

Nine blasts with cylindrical granite specimens were carried out under different stemming conditions. All rock had a diameter of 240 mm and length 300 mm. Explosive Pentaerythritol tetranitrate (PETN) specific charges 0.2 0.3 kg/m3 used, the in large explosion chamber. Each specimen was enclosed by steel box chamber during blasting, without constraint or confinement to from lateral top sides. Du...

Cancer cells exhibit an abnormal amino acid metabolism and a dependence on specific amino acids, which might provide potential targets for treating cancer patients. In this study, we demonstrated that human triple negative breast cancer (TNBC) cells were highly susceptible to cystine starvation. We found that necrostatin-1 (Nec-1, a RIP1 inhibitor), necrosulfonamide (an MLKL inhibitor), deferox...