Many women in their reproductive years experience some mood, behavioral, or physical symptoms in the week prior to menses. Women experiencing mild symptoms may have a wide variability in the level of symptom burden, whereas a minority suffers severe and debilitating symptoms. Severe premenstrual syndrome (PMS) affects 3% to 5% of women of reproductive age and has been classified under the Diagn...

The inclusion of research diagnostic criteria for premenstrual dysphoric disorder (PMDD) in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, recognizes the fact that some women have extremely distressing emotional and behavioural symptoms premenstrually. PMDD can be differentiated from premenstrual syndrome (PMS), which presents with milder physical symptoms, headache, an...

BACKGROUND Some women with depressive disorders experience severe premenstrual symptoms. However, there have been few studies in which premenstrual symptoms in women suffering from depressive disorders were assessed. In this study, we aimed to investigate premenstrual symptoms in women with depressive disorders using the premenstrual dysphoric disorder (PMDD) scale. METHODS We administered qu...

symptoms so that effective therapy can be started. How are PMS and PMDD diagnosed? The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV ), describes the 11 groups of symptoms instrumental in establishing a diagnosis of PMDD: (1) feeling sad, hopeless; (2) feeling tense, anxious; (3) lability of mood; (4) persistent irritability; (5) decreased interest in usual activ...

Premenstrual symptoms are extremely common among women of reproductive age. As many as 75% of women report minor or isolated premenstrual symptoms, up to 50% of women are estimated to have premenstrual syndrome (PMS), and 3% to 5% of women are considered to have severe PMS or premenstrual dysphoric disorder (PMDD) [1,2]. PMDD has been defined as a psychophysiological disorder in which both soma...

This study assesses the efficacy and safety of a 24-day regimen of drospirenone-containing combined oral contraceptive, and demonstrates that it is an effective and safe option for contraception, releasing symptom of premenstrual dysphoric disorder and acne in Korean women.

OBJECTIVE To compare the efficacy of a new low-dose oral contraceptive pill (OCP) formulation with placebo in reducing symptoms of premenstrual dysphoric disorder. METHODS This multicenter, double-blind, randomized clinical trial consisted of 2 run-in and 3 treatment cycles with daily symptom charting; 450 women with symptoms of premenstrual dysphoric disorder were randomized to either placeb...

The cerebellum constitutes ten percent of brain volume and contains the majority of brain neurons. Although it was historically viewed primarily as processing motoric computations, current evidence supports a more comprehensive role, where cerebro-cerebellar feedback loops also modulate various forms of cognitive and affective processing. Here we present evidence for a role of the cerebellum in...