Bone mineral density (BMD) achieved during young adulthood (peak BMD) is one of the major determinants of osteoporotic fracture in later life. Genetic variants associated with BMD have been identified by three recent genome-wide association studies. The most significant single-nucleotide polymorphisms (SNPs) from these studies were genotyped to test whether they were associated with peak BMD in...

A study was performed to clarify the clinicopathological differences between premenopausal endometrial carcinoma, which occurs during the reproductive period, and postmenopausal endometrial carcinoma. We analyzed 76 patients with endometrial carcinoma treated in our department between January 1984 and July 1994. Using classification criteria which included menstrual history and results of endoc...

BACKGROUND Adolescence may be a period of increased susceptibility to breast cancer due to regular division of undifferentiated cells that occurs between puberty and first birth. Red meat consumption during early adult life has been associated with breast cancer, but intake during adolescence has not been examined prospectively. We aimed to assess the relationship between red meat intake during...

We examined the efficacy of chemoendocrine therapy using capecitabine as a chemotherapeutic agent in premenopausal and postmenopausal models with estrogen receptor (ER)-positive human breast cancer xenografts. Tamoxifen and letrozole were used as endocrine therapeutic agents for premenopausal and postmenopausal models, respectively. The antitumor ...

PURPOSE Menopause can affect the reportedly inverse association between adiponectin and blood pressure (BP); however, this relationship is still poorly understood. The present study cross-sectionally compared the relationship between adiponectin and BP in pre- and postmenopausal women. METHODS Healthy, asymptomatic women on no medication (n = 262) were divided into a premenopausal group (n = ...

BACKGROUND AND PURPOSE Hemodynamic factors seem to play an important role in the pathogenesis of cerebral ischemic events. The aim of this study was to evaluate whether changes in cerebrovascular reactivity occur in women after menopause. METHODS Using transcranial Doppler ultrasonography, we studied the changes of flow velocity after hypercapnia in the middle cerebral arteries of 45 healthy ...

Insulin-like growth factors (IGFs) and insulin-like growth factor-binding proteins (IGFBPs) play a role in the normal development of breast tissue and possibly in the etiology of breast cancer. Breast density is one of the strongest predictors of breast cancer. In a cross-sectional analysis within the Nurses' Health Study, we compared the associations of plasma levels of endogenous IGF-I and IG...

Background/Aims: Endometrial thickening is a nonspecific finding in women with premenopausal bleeding. Though it is expected in the luteal phase of ovulatory cycle or with anovulatory bleeding, it can be due to hyperplasia, polyps, leiomyomas, or endometrial carcinoma. Three-dimensional ultrasonography is an imaging technique that allows unique ways of assessing uterine and adnexeal pathology. ...

Abstrak: Breast cancer is the most common carcinoma in women world. Anti-Mullerian Hormone (AMH) a hormone secreted by primary, secondary, and small antral ovarian follicles of <4mm. The chemotherapy regimen toxic to 5-fluorouracil-doxorubicin-cyclophosphamide (FAC). In Indonesia, there had been no study on effect FAC AMH premenopausal breast patients. This aims determine employed prospectiv...

Many young women with anorexia nervosa develop premenopausal osteoporosis. In particular, female athletes have a much higher incidence of disordered eating than their peers and therefore are at a much higher risk of stress fractures and other traumatic bone pathology. This review summarizes factors affecting the development of premenopausal osteoporosis in these patients and identifies potentia...