نتایج جستجو برای: prefoldin

تعداد نتایج: 143  

2015
Jinyang Zhang Qinqin Han Yuzhu Song Qiang Chen Xueshan Xia

BACKGROUND Rabies virus (RABV) is one of the old deadly zoonotic viruses. It attacks the central nervous system and causes acute encephalitis in humans and animals. Host factors are known to be essential for virus infection and replication in cells. The identification of the key host factors required for RABV infection may provide important information on RABV replication and may provide new po...

Journal: :Journal of computational biology : a journal of computational molecular cell biology 2011
Mark D. M. Leiserson Diana Tatar Lenore Cowen Benjamin J. Hescott

A new method based on a mathematically natural local search framework for max cut is developed to uncover functionally coherent module and BPM motifs in high-throughput genetic interaction data. Unlike previous methods, which also consider physical protein-protein interaction data, our method utilizes genetic interaction data only; this becomes increasingly important as high-throughput genetic ...

2017
Philippe Cloutier Christian Poitras Mathieu Durand Omid Hekmat Émilie Fiola-Masson Annie Bouchard Denis Faubert Benoit Chabot Benoit Coulombe

The R2TP/Prefoldin-like (R2TP/PFDL) complex has emerged as a cochaperone complex involved in the assembly of a number of critical protein complexes including snoRNPs, nuclear RNA polymerases and PIKK-containing complexes. Here we report on the use of multiple target affinity purification coupled to mass spectrometry to identify two additional complexes that interact with R2TP/PFDL: the TSC1-TSC...

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