Study objective—Evaluating the costs, eVects, and savings of several strategies for cystic fibrosis (CF) gene carrier screening. Design—A general model for evaluating prenatal, preconceptional, school, and neonatal carrier screening was constructed. For prenatal and preconceptional screening, two strategies were evaluated: single entry and double entry two step couple screening. Firstly, the Du...

Women with type 2 diabetes were less likely to have diabetes related complications than women with type 1. Women with type 1 diabetes had a high prepregnancy care and showed a worse glycemic control than women with type 2 both in the preconception period and during pregnancy. Obstetrical outcomes showed that preeclampsia and stillbirth rate is almost doubled in type 1 patients while perinatal d...

weight gain and the rate of caesarean deliveries were lower in type 2 diabetes. Gestational age at birth was significantly higher and the rate of large infants for gestational age lower in infants of women with type 2 diabetes. The rates of perinatal mortality and major congenital malformations were comparable in both groups. First-trimester A1C in type 2 and type 1 diabetic mothers with perina...

Abstract Background Pneumonia is the leading cause of death and hospitalization among young children worldwide, but its risk factors remain unclear. Objective To evaluate effect maternal exposure to diurnal temperature variation (DTV) during preconceptional prenatal periods on childhood pneumonia. Methods A retrospective cohort study by case-control design was conducted for pneumonia ( N = 699)...

Complications associated with preeclampsia (PE) include fetal growth retardation, premature birth, prenatal and postpartum hemorrhage, perinatal loss, more. Obese women have an increased risk of developing PE, probably due to impaired placental development altered metabolic homeostasis. The aim was generalize current knowledge about the role factors obesity hypercholesterolemia in PE emphasis o...

OBJECTIVE Higher heme iron intake is associated with increased type 2 diabetes risk. However, no previous study has evaluated gestational diabetes mellitus (GDM) risk in relation to heme iron intake during pregnancy. We investigated associations of maternal preconceptional and early pregnancy heme and nonheme iron intake with subsequent GDM risk. RESEARCH DESIGN AND METHODS We conducted a pro...

Extremely low frequency magnetic fields (ELF-MFs) have been classified as possibly carcinogenic to humans by the International Agency for Research on Cancer. The authors investigated, in a population-based case-control study in Germany, if children whose parents were exposed preconceptionally at work to ELF-MFs had an increased risk of developing cancer. Cases aged 0-14 years were ascertained f...

Extremely low frequency magnetic fields (ELF-MFs) have been classified as possibly carcinogenic to humans by the International Agency for Research on Cancer. The authors investigated, in a population-based casecontrol study in Germany, if children whose parents were exposed preconceptionally at work to ELF-MFs had an increased risk of developing cancer. Cases aged 0–14 years were ascertained fr...

Preconceptional diabetes management is an important prerequisite for pregnancy planning and its value has been well-documented. Glucose control and the outcome of pregnancy, managed in the preconceptional period, with continuous subcutaneous insulin infusion therapy to those receiving insulin injections are compared. Fifty-two juvenile onset insulin dependent diabetic women contemplating pregna...