Right ventricular dysfunction and significant tricuspid regurgitation are frequently seen in end stage heart failure patients undergoing Left Ventricular Assist Device (LVAD) implantation. Clinical impact of tricuspid valve repair at the time of LVAD implantation in patients with pre-existing significant tricuspid regurgitation has been a topic of debate for several years. Some groups have advo...

This paper presents the first two successful cases of pre-implantation genetic diagnosis in Hong Kong and discusses the indications and the advantages over prenatal diagnosis. Patients should be informed about the procedure and extensively counselled about the possibility of misdiagnosis and the need for conventional prenatal diagnosis during pregnancy.

Currently, no early pregnancy marker has been identified in the bitch. However, significantly decreased concentrations of heat-shock protein (HSP) 70 and increased activity of matrix metalloproteinases (MMP) 2,9 were detected in serum from bitches during the pre-implantation period between days 5 and 13 after mating, that is, 2-3 days after ovulation as determined by the measurement of progeste...

BACKGROUND AND PURPOSE Tantalum rod implantation has recently been proposed for treatment of early stages of femoral head osteonecrosis.The purpose of our study was to report the early results of its use in pre- and post-collapse stages of the disease. METHODS We studied prospectively 27 patients who underwent tantalum rod implantation for treatment of nontraumatic femoral head osteonecrosis ...

Single cell technology has been widely used in developmental and stem cell biology. In mouse, single cell transcriptome has revealed the cell lineage specification in pre-implantation and post-implantation stage embryo. Now Mohammed et al. investigated the dynamic cell fate commitment during the transition from peri-implantation to early post-implantation stage with single cell RNA sequencing. ...

OBJECTIVE Verify if late cochlear implantation allows pre-lingual deafs to convert from visual to oral communication mode only. METHOD Thirteen pre-lingual profoundly deaf patients implanted the ages of 8 and 22 years were included in the study. Before cochlear implantation, none of the patients used the oral language. Six patients used cued speech and seven used the sign language to communic...

abstract background: the aim of this study was to determine the auditory performance of congenitally deaf children and the effect of cochlear implantation (ci) on speech intelligibility. methods: aprospective study was undertaken on 47 children in a pediatric tertiary referral center for ci. all children were deaf prelingually and were younger than 8 years of age. they were followed up until 5 ...

The distribution and intensity of delta 5-3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) activity was examined histochemically in ovaries from Mongolian gerbils during pregnancy and undergoing lactational delay. In all of the ovaries examined the corpora lutea showed the strongest level of activity, but like the interstitium and granulosa, there was no relationship between the enzyme pattern ...

In mammals, the time period that follows fertilization is characterized by extensive chromatin remodeling, which enables epigenetic reprogramming of the gametes. Major changes in chromatin structure persist until the time of implantation, when the embryo develops into a blastocyst, which comprises the inner cell mass and the trophectoderm. Changes in DNA methylation, histone variant incorporati...

BACKGROUND After fertilization, embryo development involves differentiation, as well as development of the fetal body and extra-embryonic tissues until the moment of implantation. During this period various cellular and molecular changes take place with a genetic origin, e.g. the elongation of embryonic tissues, cell-cell contact between the mother and the embryo and placentation. To identify g...