Epidemiological and in vivo studies have demonstrated that exposure to the pesticides paraquat (PQ) and maneb (MB) increase the risk of developing Parkinson's disease (PD) and cause dopaminergic cell loss, respectively. PQ is a well-recognized cause of oxidative toxicity; therefore, the purpose of this study was to determine if MB potentiates oxidative stress caused by PQ, thus providing a mech...

Paraquat (PQ) poisoning-induced pulmonary fibrosis is one of the primary causes of death in patients with PQ poisoning. Hypoxia-inducible factor-1α (HIF-1α) and epithelial-mesenchymal transition (EMT) are involved in the progression of pulmonary fibrosis. Snail and β-catenin are two other factors involved in promoting EMT. However, the relationship among HIF-1α, Snail and β-catenin in PQ poison...

The Arabidopsis AtCRK5 protein kinase is involved in the establishment of proper auxin gradient many developmental processes. Among others, Atcrk5-1 mutant was reported to exhibit a delayed gravitropic response via compromised PIN2-mediated transport at root tip. Here, we report that this phenotype correlates with lower superoxide anion (O2•?) and hydrogen peroxide (H2O2) levels but higher nitr...

Let D:= (X,B,I) be a 2-design. For each xeX set Bx:= {jeB:xIj}, and define Xh dually for each h e B. We call D reduced if Xh = Xt implies that h = i for all h,ieB. Assume that D is a reduced 2-design with parameters v, b, k, r, X. Let G be a flag transitive automorphism group of D. By F*(G) we mean (as usual) the generalized Fitting subgroup of G which is defined to be the inverse image in G of...

BACKGROUND The most common cause of death from paraquat (PQ) poisoning is respiratory failure from pulmonary fibrosis, which develops through pathological overproduction of extracellular matrix proteins such as collagens. In this study, a MicroCT system was used to observe dynamic changes of pulmonary fibrosis in rats with PQ poisoning, and find the characteristics of interstitial lung diseases...

BACKGROUND Paraquat (PQ) intoxication causes lung oxidative stress damage. Saturated hydrogen saline, a newly explored antioxidant, has been documented to play a powerful antioxidant role in preventing oxidative stress damage. This study aimed to investigate the protective effects and the possible mechanisms of intoxication on rats with acute lung injury (ALI) caused by paraquat poisoning. ME...

An intelligent control strategy is proposed in this paper which suggests the Optimum Power Quality Enhancement (OPQE) of grid-connected hybrid power systems with solar photovoltaic, wind turbines, and battery storage. Unified Conditioner Active Reactive (UPQC-PQ) designed Atom Search Optimization (ASO) based Fractional-order Proportional Integral Derivative (FOPID) controller Hybrid Renewable E...

BACKGROUND To evaluate the efficacy of combined treatment with bone marrow mesenchymal stem cell (BMSC) transplantation and methylprednisolone (MP) to treat paraquat (PQ)-induced acute lung injury. MATERIALS AND METHODS A total of 102 female rats were randomly divided into five groups: PQ, BMSC, MP, BMSC + MP and normal control. After 14 days of PQ poisoning, the survival of rats, wet/dry wei...

The positive effect of melatonin on the function of the photosynthetic apparatus is known, but little is known about the specific mechanisms of melatonin's action in plants. The influence of melatonin on chlorophyll metabolism of 24-day-old Pisum sativum L. seedlings during paraquat (PQ)-induced oxidative stress was investigated in this study. Seeds were hydro-primed with water (H), 50 and 200 ...

Background: The WHO recommends that adults with uncomplicated P. falciparum successfully treated with a blood schizonticide receive a single dose of primaquine (PQ) 45 mg as a gametocytocidal agent. An earlier pilot study suggested that 75 mg of bulaquine (BQ), of which PQ is a major metabolite, may be a useful alternate to PQ. Methods: In a randomized, partial blind study, 90 hospitalized adul...