2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine, was tested for its ability to inactivate cytochrome P450s (P450s) 2B1 and 2B6. PPP inactivated the 7-(benzyloxy)resorufin O-dealkylation activity of liver microsomes obtained from phenobarbital-induced rats with a K(I) of 11 microM. The 7-ethoxy-4-(trifluoromethyl)coumarin O-deethylation activity of purified rat liver P450 2B1...

Prepubertal periodontitis (PPP) is a rare and rapidly progressive disease of young children that results in destruction of the periodontal support of the primary dentition. The condition may occur as part of a recognised syndrome or may occur as an isolated finding. Both autosomal dominant and recessive forms of Mendelian transmission have been reported for PPP. We report a consanguineous Jorda...

Evaluating the sustainability risk level of public–private partnership (PPP) projects can reduce project risk incidents and achieve the sustainable development of the organization. However, the existing studies about PPP projects risk management mainly focus on exploring the impact of financial and revenue risks but ignore the sustainability risks, causing the concept of “sustainability” to be ...

BACKGROUND Persistent postoperative pain (PPP) is defined as persistent pain after surgery of greater than three months' duration. OBJECTIVES Identify the incidence of PPP in our hospital and its associated factors; evaluate quality of life (QoL) and treatment of patients. PATIENTS AND METHODS We conducted an observational prospective study in adults proposed to various types of surgery usi...

Over the past few decades public-private partnership (PPP) models adopted by governments for infrastructure development throughout the world have evolved continuously. This article develops a dynamic framework which argues that PPP models evolve when some of the critical success factors (CSFs) for PPP are changed/improved over time based on project sponsors' risk management. The framework consi...

conclusions according to the results, total direct medical costs for hcv patients in iran exceeded 12 billion ppp$ in (inf-rbv) treatment and 55 billion ppp$ in (peg-rbv). results average direct medical costs for the courses treated with conventional interferon plus ribavirin (inf-rbv) were 4,403 ppp$, and 20,010 ppp$ for peg-interferon plus ribavirin (peg-rbv) courses. there was an increase of...

Precise Point Positioning (PPP) is a popular technology for precise applications based on the Global Navigation Satellite System (GNSS). Multi-GNSS combined PPP has become a hot topic in recent years with the development of multiple GNSSs. Meanwhile, with the operation of the real-time service (RTS) of the International GNSS Service (IGS) agency that provides satellite orbit and clock correctio...

This document defines extensions to the Layer Two Tunneling Protocol (L2TP) for enhanced support of link-specific Point to Point Protocol (PPP) options. PPP endpoints typically have direct access to the common physical media connecting them and thus have detailed knowledge about the media that is in use. When the L2TP is used, the two PPP peers are no longer directly connected over the same phy...

Positive relationships between heterotrophic bacteria and particulate phytoplankton production (respectively, BP and PPP) have been reported for several areas, suggesting that material produced by phytoplankton was a major substrate for bacterial growth. Since then, thousands of simultaneous measurements of both PPP and BP have been performed. A review of these data showed that BP may exceed PP...