Rosiglitazone (rosi) is a powerful insulin sensitizer, but serious toxicities have curtailed its widespread clinical use. Rosi functions as a high-affinity ligand for PPARgamma, the adipocyte-predominant nuclear receptor (NR). The classic model of NR action, involving binding of ligand to the NR on DNA, explains positive regulation of gene expression, but both ligand-dependent transcriptional r...

Sebaceous glands (SG) produce and secrete lipids onto the skin surface to protect it from dehydration harmful pathogens. Peroxisome proliferator-activated receptor-gamma (PPARg) is a member of nuclear receptor family ligand-activated transcription factors that critical for SG formation. Here, we report PPARg initially expressed within transitional basal cells in progenitor compartment. Lineage ...

Osteoporosis is a complex metabolic bone disorder. Recently it has been appreciated that the "obesity in bone" phenomenon occurs at the expense of bone formation, and that is a key component of the pathology of this disease. Mouse models with altered bone expression levels of peroxisome proliferator-activated receptor gamma (PPARG) impact bone formation, but genetic studies connecting PPARG pol...

Keyword: tivity of common cancer cell lines to PPARg agonists in a DOK1-dependent manner. The potential for repurposing of PPARg agonists, an established class of anti-diabetic medications, is one of the practical implications of the results of the Burgermeister et al. paper. As for the clinical relevance, the authors demonstrate that the loss of DOK1 expression portends worse survival in patie...

We investigated the effects of fasting on gene expression and intracellular signals regulating energy metabolism in adipose tissue. Following fasting for 15 h or 39 h, epididymal fat pads were isolated from Wistar rats. PPARg mRNA levels decreased in the adipose tissues isolated from rats fasted for 39 h, whereas adipocyte lipid-binding protein (aP2) and lipoprotein lipase (LPL) mRNA levels inc...

Postmenopausal osteoporosis is a systemic skeletal disease characterized by decrease in bone mass and disruption of the microarchitecture, resulting increased fragility. DXA scan (dual-energy X-ray absorptiometry) "gold standard" for diagnosis osteoporosis, while different serum or urine biomarkers are used measurement turnover. PPAR-g belongs to family non-steroid nuclear receptors. It predomi...

The tropical freshwater zebrafish has recently emerged as a valuable model organism for the study of adipose tissue biology and obesity-related disease. The strengths of the zebrafish model system are its wealth of genetic mutants, transgenic tools, and amenability to high-resolution imaging of cell dynamics within live animals. However, zebrafish adipose research is at a nascent stage and many...

The peroxisome proliferator-activated receptor-gamma gene (PPARG) has been implicated in the etiology of type 2 diabetes mellitus and has been investigated in numerous epidemiologic studies. In this Human Genome Epidemiology review, the authors assessed this relation in an updated meta-analysis of 60 association studies. Electronic literature searches were conducted on September 14, 2009. Popul...

AIMS/INTRODUCTION Peroxisome proliferator activated receptor gamma (PPARG) is a nuclear hormone receptor of the ligand-dependent transcription factor involved in adipogenesis, and a molecular target of the insulin sensitizer, thiazolidinediones. The present study aimed to investigate whether the PPARG gene is associated with type 2 diabetes mellitus and its related traits within the population ...

AIM To investigate the association of peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala polymorphism with polycystic ovary syndrome (PCOS) and its effect on the metabolic parameters in PCOS women. METHODS The study used PCR to identify the presence of the PPARG Pro12Ala polymorphism in 100 PCOS women and 120 age-matched healthy women. All participants were subjected to anthrop...