نتایج جستجو برای: pparγ

تعداد نتایج: 4465  

Journal: :The Journal of biological chemistry 2013
Kyeong Won Lee Jin Gu Cho Chul Min Kim A Young Kang Min Kim Byung Yong Ahn Sung Soo Chung Key-Hwan Lim Kwang-Hyun Baek Jong-Hyuk Sung Kyong Soo Park Sang Gyu Park

The peroxisome proliferator-activated receptor γ (PPARγ) is a central regulator of adipogenesis and modulates glucose and lipid metabolism. In this study, herpesvirus-associated ubiquitin-specific protease (HAUSP) was isolated as a binding partner of PPARγ. Both endogenous and exogenous PPARγ associated with HAUSP in co-immunoprecipitation analysis. HAUSP, but not the catalytically inactive HAU...

Journal: :Infection and immunity 2016
Brahmchetna Bedi Zhihong Yuan Myungsoo Joo Susu M Zughaier Joanna B Goldberg Jack L Arbiser C Michael Hart Ruxana T Sadikot

The pathogenic profile of Pseudomonas aeruginosa is related to its ability to secrete a variety of virulence factors. Quorum sensing (QS) is a mechanism wherein small diffusible molecules, specifically acyl-homoserine lactones, are produced by P. aeruginosa to promote virulence. We show here that macrophage clearance of P. aeruginosa (PAO1) is enhanced by activation of the nuclear hormone recep...

Journal: :The Journal of pharmacology and experimental therapeutics 2011
Araní Casillas-Ramírez Izabel Alfany-Fernández Marta Massip-Salcedo M Emília Juan Joana M Planas Anna Serafín Mercè Pallàs Antoni Rimola Juan Rodés Carmen Peralta

Numerous steatotic livers are discarded for transplantation because of their poor tolerance of ischemia-reperfusion (I/R). The injurious effects of retinol-binding protein 4 (RBP4) in various pathologies are well documented. RBP4 levels are reduced by peroxisome proliferator-activated receptor-γ (PPARγ) agonists. Strategies aimed at increasing PPARγ protect steatotic livers under warm ischemia....

Journal: :Journal of immunology 2012
Sesquile Ramon Simona Bancos Thomas H Thatcher Thomas I Murant Safiehkhatoon Moshkani Julie M Sahler Andrea Bottaro Patricia J Sime Richard P Phipps

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. PPARγ, a ligand-activated transcription factor, has important anti-inflammatory and antiproliferative functions, and it has been associated with diseases including diabetes, scarring, and atherosclerosis, among others. PPARγ is expressed in most bone marrow-derived cells and influences t...

2017
Ai N.H. Phan Vu T.A. Vo Tuyen N.M. Hua Min-Kyu Kim Se-Young Jo Jong-Whan Choi Hyun-Won Kim Jaekyoung Son Young-Ah Suh Yangsik Jeong

Metabolic reprogramming as a crucial emerging hallmark of cancer is critical for tumor cells to maintain cellular bioenergetics, biosynthesis and reduction/oxidation (REDOX) balance. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear hormone receptor regulating transcription of diverse gene sets involved in inflammation, metabolism, and suppressing tumor growth. Thiazolidined...

2011
Kyeong Won Lee Yun Hyi Ku Min Kim Byung Yong Ahn Sung Soo Chung Kyong Soo Park

BACKGROUND Sulfonylurea primarily stimulates insulin secretion by binding to its receptor on the pancreatic β-cells. Recent studies have suggested that sulfonylureas induce insulin sensitivity through peroxisome proliferator-activated receptor γ (PPARγ), one of the nuclear receptors. In this study, we investigated the effects of sulfonylurea on PPARγ transcriptional activity and on the glucose ...

2009
Bing Zou Liang Qiao Benjamin C. Y. Wong

Numerous studies have indicated that PPARγ plays multiple roles such as in inflammation, cell cycle control, cell proliferation, apoptosis, and carcinogenesis, thus PPARγ contributes to the homeostasis. Many in vitro studies have showed that ligand-induced activation of PPARγ possess antitumor effect in many cancers including CRC. However, the role of PPARγ in gastrointestinal cancers, especial...

Journal: :The EMBO journal 2013
Lifeng Wang Shiliyang Xu Ji-Eun Lee Anne Baldridge Sean Grullon Weiqun Peng Kai Ge

PPARγ promotes adipogenesis while Wnt proteins inhibit adipogenesis. However, the mechanisms that control expression of these positive and negative master regulators of adipogenesis remain incompletely understood. By genome-wide histone methylation profiling in preadipocytes, we find that among gene loci encoding adipogenesis regulators, histone methyltransferase (HMT) G9a-mediated repressive e...

Journal: :Cell 2012
Paul A. Dutchak Takeshi Katafuchi Angie L. Bookout Jang Hyun Choi Ruth T. Yu David J. Mangelsdorf Steven A. Kliewer

Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially affects carbohydrate and lipid metabolism. Here, we report that FGF21 is also an inducible, fed-state autocrine factor in adipose tissue that functions in a feed-forward loop to regulate the activity of peroxisome proliferator-activated receptor γ (PPARγ), a master transcriptional regulator of adipogenesis. FGF21 ...

Mahzad Mehrzad-Sadaghiani Maryam Darabi Masoud Darabi Mina Zaree Mohammad Nouri, Sajjad Khani Shabnam Fayezi Vahideh Shahnazi

Background The omega-3 fatty acid (ω-3 fatty acid) such as eicosapentaenoic acid (EPA) is currently used in the clinic as a nutritional supplement in the treatment of polycystic ovarian syndrome (PCOS). The present study was designed to investigate the effect of EPA on the expression levels of peroxisome proliferator-activated receptor gamma (PPARγ) and cytochrome P450 aromatase (encoded by the...

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