Typically, immune responses control the pathogen, while repair and stress pathways limit damage caused by pathogenesis. The relative contribution of damage to the outcome of pathogenesis and the mechanistic links between the immune and repair pathways are poorly understood. Here, we analyze how the entomopathogenic bacterium Pseudomonas entomophila induces irreversible damage to the Drosophila ...

A huge number of deaths in the world are the direct or indirect consequence of a disease which is called atherosclerosis. The disease could be due to an artery blockage by the interaction of an externally second phase with a particle which is entered to the bloodstream. The effect of some most important physical and geometrical affecting parameters on the blockage time of a microchannel due to ...

Ischemic heart diseases (IHD) have become the leading cause of death around the world, killing more than 7 million people annually. In IHD, the blockage of coronary vessels will cause irreversible cell injury and even death. As the "powerhouse" and "apoptosis center" in cardiomyocytes, mitochondria play critical roles in IHD. Ischemia insult can reduce myocardial ATP content, resulting in energ...

Listeriolysin O (LLO), an essential virulence determinant of Listeria monocytogenes, is a pore-forming toxin whose primary function is to facilitate cytosolic bacterial replication by breaching the phagosomal membranes, which is critical for the pathogen to evade host immune recognition. The critical role of LLO in the virulence of L. monocytogenes renders it an ideal target for designing novel...

The pore size of the chabazite structure is exceptionally suitable for methanol to olefins (MTO) reaction. reaction has an induction period required formation a hydrocarbon pool (HP), usually composed aromatic compounds different sizes. HP alkylated by and afterward cracked, leading olefins. Despite importance HP, its growth in are exceedingly dependent on porosity catalyst. ideal that formed r...

development of pore network models for real porous media requires a detailed understanding of physical processes occurring on the microscopic scale and a complete description of porous media morphology. in this study, the microstructure of porous media has been represented by three dimensional networks of interconnected pores and throats which are designed by an object oriented approach. afterw...

Water flooding technology is an important measure to enhance oil recovery in oilfields. Understanding the pore-scale flow mechanism water process of great significance for optimization development schemes. Viscous action and capillarity are crucial factors determination rate flooding. In this paper, a direct numerical simulation (DNS) method based on Navier–Stokes equation volume fluid (VOF) em...

The discharge of groundwater and the load on lining structure are both significantly impacted by obstruction tunnel drainage system. In this study, fluid–structure interaction model was established based finite difference software FLAC3D. Then, research explored effects symmetric asymmetric blockage in circular drainpipe, transverse drainpipe at pipe joint pore water pressure, displacement stre...

TMEM16A and TMEM16B encode for Ca2+-activated Cl- channels (CaCC) and are expressed in many cell types and play a relevant role in many physiological processes. Here, I performed a site-directed mutagenesis study to understand the molecular mechanisms of ion permeation of TMEM16B. I mutated two positive charged residues R573 and K540, respectively located at the entrance and inside the putative...