Signal and stop transfer sequences are discrete regions within a polypeptide chain able to initiate or terminate translocation of the protein across the membrane of the endoplasmic reticulum. We have investigated the role of these topogenic sequences in the biogenesis of polytopic transmembrane proteins. Plasmids encoding various patterns of well-characterized signal and stop transfer sequences...

The problems of robust stability for a class of the polytopic-type uncertain singular stochastic systems with time-varying delays are studied. By using a delay decomposition approach and terms of linear matrix inequalities (LMIs), robust stability criteria ensuring globally stochastically asymptotic stability of the polytopic-type uncertain singular stochastic systems with time-varying delays a...

In this paper, the delay-dependent robust control problem is considered for time-delay systems with polytopic uncertainty. Robust stabilizing controller and robust H∞ controller are designed by using a parameter-dependent Lyapunov function that can reduce the conservativeness when used in robust performance analysis and synthesis problems for polytopic systems. Furthermore, multichannel H∞ dyna...

Polytopic cryptanalysis was introduced at EUROCRYPT 2016 as a cryptanalytic technique for low-data-complexity attacks on block ciphers. In this paper, we give an account of how the technique was developed, quickly go over the basic ideas and techniques of polytopic cryptanalysis, look into how the technique differs from previously existing cryptographic techniques, and discuss whether the attac...

Polytopic membrane proteins are inserted cotranslationally into target membranes by ribosome-translocon complexes. It is, however, unclear when during the insertion process specific interactions between the transmembrane helices start to form. Here, we use a recently developed in vivo technique to measure pulling forces acting on transmembrane helices during their cotranslational insertion into...

Ellipsoidal invariant sets have been widely used as target sets in MPC. These sets can be computed by constructing appropriate Linear Difference Inclusions together with additional constraints to ensure that the ellipsoid lies within a given Inclusion Polytope. The choice of this polytope has a significant effect on the size of the computed ellipsoid, but the optimal inclusion polytope cannot i...

The prediction and design at the atomic level of membrane protein structures and interactions is a critical but unsolved challenge. To address this problem, we have developed an all-atom physical model that describes intraprotein and protein-solvent interactions in the membrane environment. We evaluated the ability of the model to recapitulate the energetics and structural specificities of poly...