Sir: Clozapine is an antipsychotic medication introduced to the United States in 1989. It is a tricyclic dibenzodiazepine derivative chemically related to the traditional antipsychotic medication loxapine. 1 Side effects pose a significant problem during clozapine therapy. Adverse reactions occur most frequently during the initiation of clozapine treatment and during the acute treatment and dos...

Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterized by episodic fever and inflammatory polyserositis, which could lead to a variety of manifestations, including recurrent abdominal pain. Herein, a 12-year-old boy who has suffered from fever and bloody diarrhea since early childhood is described. All structural and underlying disorders leading to bleeding we...

Introduction Familial Mediterranean fever (FMF) is characterized by acute and recurrent attacks of fever and polyserositis. It is associated with conduction disturbances and rhythm abnormalities. Heart rate variability (HRV) is the term used to indicate the fluctuation in cardiac frequency over time. HRV analysis is used to evaluate the condition of the autonomous nervous system, which regulate...

Introduction Cutaneous Polyarteritis Nodosa (cPAN) is a rare type of vasculitis affecting small-to-medium-size arteries. It is distinct from systemic PAN in that it lacks significant internal organ involvement. Familial Mediterranean Fever (FMF) is the most common inherited autoinflammatory disease, characterized by recurrent, self–limited attacks of fever and aseptic polyserositis. PAN is cons...