Organic/inorganic nanohybrid materials have attracted particular scientific and technological interest because they combine the properties of the organic and the inorganic component. Inorganic nanoparticles exhibit interesting electrical, optical, magnetic and/or catalytic properties, which are related with their nano-scale dimensions. However, their high surface-to-volume ratio often induces a...

Interface issues are common and crucial in nanocomposites or nanohybrid systems since the interface area is enormous on the nanoscale. In the 0-3 polymer nanocomposites, in which nano-inclusions (0-dimension) are embedded in 3-dimensionally connected polymer matrix, enhanced dielectric permittivity could be induced by the interfacial polarization at the interfaces between the nano-inclusions an...

Optical coherence tomography (OCT) is a high resolution imaging modality and has been considered as the ideal tool for the evaluation of neointimal tissue and vascular responses following stent implantation. However, vascular response profiles following the implantation of a novel nano polymer-free sirolimus-eluting stent (SES) assessed by OCT has not been fully investigated. Therefore, the aim...

Our paper reviews the use of conductive polymer composite materials in various applications for semi conductive, static-dissipative, anti-corrosive, electromagnetic interference (EMI) shielding and stealth composite coatings. The composite consists of conductive fillers and the insulating polymer network. The composite becomes electrically conductive as the filler content exceeds a certain crit...

In Germany, four different drug eluting stents (DES) systems are currently commercially available. Whereas sirolimus has been clinically tested in only a single type of stent with a single type of coating in only a single dose, paclitaxel has been tested on various stent designs, in various dose densities, and in various release formulations with or without a polymer carrier. Therefore, the que...

Self-assembly of amphiphilic polymer opens a new avenue in the biomedical field; particularly, amphiphilic polymer vesicles have generally shown promising potential in drug delivery applications. The advantage of nanoparticle for drug delivery is because of the direct injection of these kind molecules to the body which will circulate in the body without any coagulation or blocking. The amphiphi...

Nanogels are nano-sized three-dimensional polymer networks engineered by physical or chemical cross-linking of individual polymer chains loaded with drugs and nucleotides that swells in a good solvent

Objective(s): Development of an oral sustained-controlled release vehicle which, slowly releases the drug and maintains an effective drug concentration for a long time is aimed.Materials and Methods: A biodegradable magnetic polymeric drug delivery vehicle, using superparamagnetic iron oxide nanoparticles encapsulating by polyvinylpyrrolidone-block-polyethylene glycol-block-poly methacrylic aci...

Tamoxifen is routinely used for treatment of Estrogen-positive breast carcinoma. Approximately, 50% of patients with metastatic cancer will develop resistance to Tamoxifen. In this research, Tamoxifen was combined with the anti-cancer compound Curcumin. Diblock nanopolymer was used to package the new formulation of Curcumin and Tamoxifen. Anti-cancer efficacy of the obtained compound was evalua...

SUPERCRITICAL CARBON DIOXIDE PROCESSING OF NANO CLAYS ANDPOLYMER/CLAY NANOCOMPOSITESbyMIHAI MANITIUAugust 2010Advisor: Rangaramanujam KannanCo-Advisor: Esin GulariMajor: Chemical EngineeringDegree: Doctor of Philosophy Effective dispersion of the fillers in a polymer matrix and improvement of polymer clayinteractions are two key challenges in the field of...