Due to their special physicochemical properties, iron nanoparticles offer new promising possibilities for biomedical applications. For bench to bedside translation of super-paramagnetic iron oxide nanoparticles (SPIONs), safety issues have to be comprehensively clarified. To understand concentration-dependent nanoparticle-mediated toxicity, the exact quantification of intracellular SPIONs by re...

In regenerative medicine, noncontact manipulation of cells enables new possibilities for tissue engineering. Due to their physicochemical properties, superparamagnetic iron oxide nanoparticles (SPIONs) are used in biomedicine various applications, e.g., as drug transporters, contrast agents or make maneuverable by magnetic forces. SPIONs attached and/or taken up enable targeting adoptive immune...

This study was designed to determine the effects of superparamagnetic iron oxide nanoparticles (SPIONs) on the biological activity of a bacterial biofilm (Streptococcus mutans). Our hypothesis was that the diffusion of the SPIONs into biofilms would depend on their surface properties, which in turn would largely be determined by their surface functionality. Bare, positively charged and negative...

Low efficiency is often observed in the delivery of DNA vaccines. The use of superparamagnetic nanoparticles (SPIONs) to deliver genes via magnetofection could improve transfection efficiency and target the vector to its desired locality. Here, magnetofection was used to enhance the delivery of a malaria DNA vaccine encoding Plasmodium yoelii merozoite surface protein MSP1(19) (VR1020-PyMSP1(19...

Background Glioblastoma is the most devastating primary brain tumor of the central nervous system in adults. Magnetic nanocarriers may help not only for a targeted delivery of chemotherapeutic agents into the tumor site but also provide contrast enhancing properties for diagnostics using magnetic resonance imaging (MRI). Methods Synthesized hybrid chitosan-dextran superparamagnetic nanopartic...

Superparamagnetic Iron Oxide Nanoparticles (SPIONs) prepared by simplified coprecipitation were attractive as MRI contrast agents and drug carriers which could internally be manipulated under the influence of an external magnetic field and also cancer treatment due to additional hyperthermia effects. Problem statement: Macrophage and liver cells are potentially exposed to internal SPIONs, thus ...

Herein we report the synthesis of water-soluble polyglycerol-dendronized perylenediimides with a single reactive group that undergoes high-yielding click reactions. Single-molecule studies and target-specific biolabeling are reported, including the highly specific labeling of proteins on the surface of living bacterial and mammalian cells.

The adsorption of viruses from aqueous solution is frequently performed to detect viruses. Charged filtration materials capture via electrostatic interactions, but lack the specificity biological virus-binding substances like heparin. Herein, we present three methods immobilize heparin-mimicking, polymers a filter material. Two mussel-inspired approaches are used, based on dopamine or dendritic...

Herein, we report the simple preparation of water dispersible angular-shaped amine-functionalized superparamagnetic iron oxide nanoparticles (A-SPIONs). A-SPIONs were synthesized by heating iron(III) acetylacetonate in a mixture of solvents containing polyethyleneglycol (PEG) and branched polyethyleneimine (b-PEI) under vigorous stirring. Both PEG and b-PEI provided high water dispersibility by...