OBJECTIVE A theory of fuzzy polynucleotides, including an n-dimensional metric fuzzy polynucleotide space, has been previously introduced by the present author for fuzzy-theoretical analysis of nucleic acids [Sadegh-Zadeh K. Fuzzy genomes. Artif Intell Med 2000;18:1-28; Sadegh-Zadeh K. Ein Verfahren zur Fuzzydecodierung und Fuzzydechiffrierung von Informationen. Offenlegungsschrift DE 199 36 92...

We investigate polyelectrolyte bridging interactions mediated by charged, flexible, polyelectrolyte chains between fixed cylindrical macroions of opposite charge in a two-dimensional hexagonal crystalline array. We show that in the asymptotic regime of small macroion density, the polyelectrolyte-mediated attraction is long range, falling off approximately linearly with the macroion array densit...

There has been considerable interest in polyelectrolyte multilayer nanofilms, which have a variety of applications ranging from optical and electrochemical materials to biomedical devices. Polyelectrolyte multilayer nanofilms are constructed from aqueous solutions using electrostatic layer-by-layer self-assembly of oppositely-charged polyelectrolytes on a solid substrate. Multifunctional polyel...

There is a very close steric relationship between the codon-anticodon site which accounts for the genetic code dictionary and a polynucleotide replicase site. Protein biosynthesis must therefore have arisen out of a primaeval polynucleotide replicase system.

Monte Carlo simulations were used to investigate the conformational and electrical properties of isolated weak polyelectrolytes in the presence of an oppositely charged particle. Titrations curves were calculated to get an insight into the role of pH on the degree of ionization and conformation of isolated chains. The effect of ionic concentration and polyelectrolyte length on the titration cur...

Background: Polyelectrolyte complexes are complexes formed by interaction of two oppositely charged ions. This study deals with formation of chitosan–Aegle marmelos polyelectrolyte complex. Polyelectrolyte complex was found to be used as pharmaceutical excipient. Aim: The present study aimed to synthesize Chitosan–Aegle marmelos polyelectrolyte complex and their characterization and to compare ...

The objective of this investigation was the development of chitosan/xanthan polyelectrolyte complex based mucoadhesive nasal insert of promethazine hydrochloride a drug used in the treatment of motion sickness. A 32 factorial design was applied for preparing chitosan/xanthan polyelectrolyte complex and to study the effect of independent variables i.e. concentration of xanthan [X1] and concentra...

The objective of this investigation was the development of chitosan/xanthan polyelectrolyte complex based mucoadhesive nasal insert of promethazine hydrochloride a drug used in the treatment of motion sickness. A 32 factorial design was applied for preparing chitosan/xanthan polyelectrolyte complex and to study the effect of independent variables i.e. concentration of xanthan [X1] and concentra...

Complexation between polyelectrolyte and polyampholyte chains in poor solvent conditions for the polyelectrolyte backbone has been studied by molecular dynamics simulations. In a poor solvent a polyelectrolyte forms a necklace-like structure consisting of polymeric globules (beads) connected by strings of monomers. The simulation results can be explained by assuming the existence of two differe...