Thyroid hormone (TH) is essential for normal brain development, but the specific actions of TH differ across developmental time and brain region. These actions of TH are mediated largely by a combination of thyroid hormone receptor (TR) isoforms that exhibit specific temporal and spatial patterns of expression during animal and human brain development. In addition, TR action is influenced by di...

The Human Health Effects of Exposure to Polybrominated Biphenyls. STROSS, J. K., SMOKLER, I. A., ISBISTER, J., AND WILCOX, K. R. (1981). Toxicol. Appl. Pharmacol. 58, 145-150. Polybrominated biphenyls (PBB) were inadvertently introduced into the food chain in Michigan in 1973. Fifty-one people with known exposure to PBB were studied. Twenty-three farmers with disabling health complaints, and 28...

Polychlorinated biphenyls (PCBs) are a widespread class of persistent organic chemicals that accumulate in the environment and humans and are associated with a broad spectrum of health effects. PCB biotransformation has been shown to lead to two classes of PCB metabolites that are present as contaminant residues in the tissues of selected biota: hydroxylated (HO) and methyl sulfone (MeSO2) PCBs...

Brominated flame retardants (BFRs) are anthropogenic compounds that ubiquitous in most manufactured goods. Few legacy BFRs have been recognised as persistent organic pollutants (POPs) and prohibited since the 2000s. However, continue to be used despite growing concerns regarding their toxicity; they often referred novel (nBFRs). While environmental contamination due chlorinated POPs has extensi...

Consulting Services Ltd., 55 p. Sellstr€ om, U., Jansson, B., Kierkegaard, A., de Wit, C., Odsj€ o, T., Olsson, M., 1993. Polybrominated diphenyl ethers (PBDE) in biological samples from the Swedish environment. Chemosphere 26, 1703–1718. Simon, M., Wakeford, B.J., 2000. Multiresidue method for the determination of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and non-ortho s...