Self-assembled polymeric nanoparticles modified with targeting ligands on the surface provide a means for localized cell delivery. To gain greater insight into the possibility of derivatizing poly(2-methyl-2-carboxytrimethylene carbonate-co-D,L-lactide) (poly(TMCC-co-LA)) nanoparticles using the Huisgen's 1,3 dipolar cycloaddition reaction, we synthesized amphiphilic copolymers comprising a hyd...

Ovarian cancer is one of the leading causes of cancer death for women throughout the Western world. Kaempferol, a natural flavonoid, has shown promise in the chemoprevention of ovarian cancer. A common concern about using dietary supplements for chemoprevention is their bioavailability. Nanoparticles have shown promise in increasing the bioavailability of some chemicals. Here we developed five ...

PURPOSE To achieve simultaneous imaging and therapy potentials, targeted fluoromagnetic nanoparticles were synthesized and examined in human breast cancer MCF-7 cells. METHODS Fe3O4 nanoparticles (NPs) were synthesized through thermal decomposition of Fe(acac)3. Then, magnetic nanoparticles (MNPs) modified by dopamine-poly ethylene glycol (PEG)-NH2; finally, half equivalent fluorescein isothi...

Synthesis and characterization of magnetic nanoparticles with excellent size control are showed here. Their functionalization using an amphiphilic polymer is also described. This strategy allows the stabilization of magnetic nanoparticles in aqueous solvents and in addition, the polymer shell serves as a platform to incorporate relevant biomolecules, such as poly(ethylene glycol) and a number o...

We report a new NMR relaxation time-based method for sensitive and selective dopamine detection using paramagnetic nanoparticles. The Fe(3+) species in the nanoparticles serves as both the contrast agent and the target recognition element. The results demonstrate that paramagnetic nanoparticles, similar to the more widely used superparamagnetic nanoparticles, can be integrated into relaxation b...

pH-sensitive drug targeting using nanoparticles for cancer chemotherapy have been spotlighted in recent decades. Graft copolymer composed of poly (L-histidine) (PHS) and dextran (DexPHS) was synthesized and pH-sensitive nanoparticles were fabricated for pH-responsive drug delivery of doxorubicin (DOX). Nanoparticles of DexPHS showed pH-sensitive changes in particle sizes and drug release behavi...

Amphotericin B (AmB)/poly(lactic acid)-b-poly(ethylene glycol) (PLA-b-PEG) nanoparticles coated with polysorbate 80 (Tween-80) were prepared by nanoprecipitation for transport across the blood-brain barrier (BBB). The effects of Tween-80 on the size and distribution, entrapment efficiency and release behavior of AmB/PLA-b-PEG nanoparticles were investigated. Furthermore, the brain targeting and...

synthesis and characterization of two functionalized gold nanoparticles by using of two poly functional amino acids (l-arginine and l-aspartic acid) are reported. the gold nanoparticles were reduced by sodium citrate and functionalized with l-arginine at the ph of 7 and 11 and l-aspartic acid at the ph of 7. transmission electron microscopy, uv-vis spectroscopy, dynamic light scattering, zeta p...

Abstract Osteoarthritis (OA) has been regarded as a lubrication deficiency related joint disease. Combination of both and drug intervention may provide promising nonsurgical strategy for treatment OA. Developing novel simple approaches to fabricate superlubricating nanoparticles with release property is highly required. Herein, dopamine triggered one-step polymerization method was employed poly...

BACKGROUND Because of the described hazards related to inhalation of manufactured nanoparticles, we investigated the lung toxicity of biodegradable poly (lactide-co-glycolide) (PLGA) nanoparticles displaying various surface properties on human bronchial Calu-3 cells. METHODS Positively and negatively charged as well as neutral nanoparticles were tailored by coating their surface with chitosan...