To develop a platform for tumor chemotherapy, poly(acrylic acid-co-methyl methacrylate) microparticles have been synthesized. Carboxylate containing monomers were included to complex therapeutic agents, specifically cisplatin. Microparticles were prepared by free radical emulsion polymerization in aqueous media. Particle diameter, zeta-potential, in vitro cytotoxicity, and in vivo acute toxicit...

A mucoadhesive drug delivery system can improve the effectiveness of a drug by maintaining the drug concentration and allowing targeting and localization of the drug at a specific site. Acrylic-based hydrogels have been used extensively as a mucoadhesive system owing to their flexibility and excellent bioadhesion. In this experiment, poly(acrylic acid) was selected to prepare the bioadhesive hy...

Five new aromatic poly(amide-imide)s (5a-e) were synthesized by direct polycondensationreaction of N-(4-carboxy phenyl) trimellitimide (3) with five aromatic diamines (4a-e) by usingtriphenyl phosphite in N-methyl-2-pyrrolidone (NMP) and pyridine at solution containingdissolved CaCl2. All of the polymers were obtained in quantitative yields with inherentviscosities between 0.29-0.40 dL/g. The r...

There is a clinical need for a synthetic bone graft substitute that can be used at sites of surgical intervention to promote bone regeneration. Poly(vinylphosphonic acid-co-acrylic acid) (PVPA-co-AA) has recently been identified as a potential candidate for use in bone tissue scaffolds. It is hypothesized that PVPA-co-AA can bind to divalent calcium ions on bone mineral surfaces to control matr...

Single Langmuir-Blodgett (LB) bilayers derived from calix[n]arene-based surfactants (n = 4, 5 and 6) and poly(acrylic acid) (PAA) exhibit exceptional H(2)/CO(2) permeation selectivities. Evidence for the importance of ionic crosslinking and self-healing processes is presented.

five new aromatic poly(amide-imide)s (5a-e) were synthesized by direct polycondensationreaction of n-(4-carboxy phenyl) trimellitimide (3) with five aromatic diamines (4a-e) by usingtriphenyl phosphite in n-methyl-2-pyrrolidone (nmp) and pyridine at solution containingdissolved cacl2. all of the polymers were obtained in quantitative yields with inherentviscosities between 0.29-0.40 dl/g. the r...

The thermally induced volume phase transition process of poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAM-co-AA) hydrogel is studied using FT-IR spectroscopy in combination with the perturbation correlation moving window (PCMW) technique and two-dimensional correlation spectroscopy (2Dcos) analysis. According to PCMW spectra analysis, an elevation of volume phase transition temperature (VPTT...