Neurodegenerative diseases are becoming prevalent as the population ages. Geniposide could inhibit oxidative stress, reduce apoptosis, protect neuron, and has been used for therapy of the neurodegenerative diseases. The bioavailability of geniposide by nasal route is greater than that by oral administration. However, mucociliary clearance is a rate-limiting factor for nasal route administration...

On the basis of elastic light scattering, we have compared the capacity of the multi-block, surfactant copolymers Poloxamer 108 (P108), Poloxamer 188 (P188), and Tetronic 1107 (T1107), of average molecular weight 4700, 8400, and 15,000, respectively, with that of polyethylene glycol (PEG, molecular weight 8000) to suppress aggregation of heat-denatured hen egg white lysozyme (HEWL) and bovine s...

•Imaged worm-like micelles and vesicles in their native solution state•Developed a strategy to produce polymer nanomaterials inside TEM liquid cell•Visualized the dynamic process of polymerization-induced self-assembly real time•Leveraged variable-temperature LCTEM investigate phase transitions Self-assembly amphiphilic block copolymers is promising manipulate soft matter on nanoscale. To under...