Recent technical advances have added greatly to the ease with which virological methods may be applied to the study of poliomyelitis and allied infection of the central nervous system. These techniques have already borne abundant fruit in the development of a vaccine against poliomyelitis. The accurate appraisal of the preventive value of such a vaccine will depend on our ability to diagnose po...

OBJECTIVE To study the trends of paralytic poliomyelitis in pre Pulse Polio Immunization period. SETTING Hospital based sentinel surveillance. METHODS Analysis of 6704 line-listed poliomyelitis cases from January 1989 to December 1994 attending the Department of Physical Medicine and Rehabilitation. RESULTS 85% of all cases reported in Delhi were from this center. A decline in alternate y...

David Bodian spent almost his whole scientific career (1942–1983) at the Johns Hopkins University, first in the Department of Epidemiology at the School of Hygiene and Public Health and then in the Department of Anatomy at the School of Medicine. Arguably, his most important research contribution was the elucidation of the pathogenesis of poliomyelitis—a contribution that played a major role in...

Immunization is an important cost effective strategy for child survival(l,2). With the inclusion of heat labile oral polio and measles vaccine in the Universal Immunization Programme, maintenance of cold chain is of paramount importance(3). Inadequate management of cold chain may reduce the potency of the oral polio vaccine to almost zero. In India 15 to 30% cases of poliomyelitis, occur in chi...

Successful implementation of the global poliomyelitis eradication program raises the problem of vaccination against poliomyelitis in the posteradication era. One of the options under consideration envisions completely stopping worldwide the use of the Sabin vaccine. This strategy is based on the assumption that the natural circulation of attenuated strains and their derivatives is strictly limi...

Abstract Since May 2019, the Central African Republic has experienced a poliomyelitis outbreak caused by type 2 vaccine-derived polioviruses (VDPV-2s). The affected Bangui, capital city, and 10 districts across country. resulted from several independent emergence events of VDPV-2s featuring recombinant genomes with complex mosaic genomes. low number mutations (<20) in viral capsid protein 1–enc...

This year the Hajj will take place during 24-29 October. Recent outbreaks of Ebola haemorrhagic fever in Uganda and the Democratic Republic of the Congo, cholera in Sierra Leone, and infections associated with a novel coronavirus in Saudi Arabia and Qatar required review of the health recommendations of the 2012 Hajj. Current guidelines foresee mandatory vaccination with quadrivalent meningococ...

India is committed to eradication of poliomyelitis by the year 2000. However, India still reported about 58% of all polio cases documented globally in 1995. India has adopted the World Health Organisation’s recommended strategy of National Immunization Days (that is, Pulse Polio Immunization) from the year 1995. Oral polio vaccine (OPV) was introduced at national level in 1985. However, no comm...

Given the actual risk of poliomyelitis outbreaks in region due to poliovirus derived from Sabin vaccine or importation wild poliovirus, Latin American Society Pediatric Infectious Diseases commissioned an ad hoc group experts institution's Vaccines and Biologicals Committee, draft official position paper on urgent need increase immunization levels against disease incorporate inactivated polio e...