The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. Although stimulation of the Fas/TNFR receptor family triggers a canonical ‘extrinsic’ apoptosis pathway, we demonstrated that in the absence of intracellular apoptotic signaling it is capable of activating a common nonapoptotic death pathway, w...

Great smiles have harmony, symmetry, and a broadness consistent with the individual’s facial form, morphology, and balance. Smiles communicate, are expressive, and especially beautiful when full. People do not perceive narrow arch smiles to be appealing. A proportional smile fills the lip embrasures and eliminates black triangles. We see this as beauty in nature, and such symmetry is preferred ...

A 37-year-old man with symptoms of cardiovascular disease applied to our hospital. Seven years ago, he had undergone combined kidney and pancreas transplantation. Afterwards, 4 years ago, his renal transplantation was repeated because of rejection. Coronary artery angiography revealed two-vessel coronary artery stenosis. We performed coronary artery bypass grafting to treat the coronary artery ...

Human activities have more than doubled inputs of nitrogen (N) to terrestrial ecosystems worldwide (1). Until recently, most of this increase was focused in the developed regions of the world. With fertilizer consumption (2), fossil-fuel emissions (3), and biomass burning (4) rapidly increasing in less developed regions, sources and distribution of anthropogenic N now occur globally (5), as doe...

We consider the optimum north-south elongation for the Millimeter Array A con guration and interferometric arrays in general. The optimum elongation depends primarily on the observational requirements of the array, with a very weak dependance on the latitude. Assuming that the Millimeter Array A con guration will be used primarily for long integrations, we nd that the optimum north-south axis r...

Intracellular parasites manipulate host cell apoptosis in different ways either to increase their life span within infected cells or to spread infection. The present data provided information on the cellular changes taking place in spleen and peripheral blood during Plasmodium berghei-infection and indicated apoptosis mediated host immune response during infection. Our results suggested a signi...

3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused illicit drug that can cause severe and even fatal adverse effects. However, interest remains for its possible clinical applications in posttraumatic stress disorder and anxiety treatment. Preclinical studies to determine MDMA’s safety are needed. We evaluated MDMA’s pharmacokinetics and metabolism in male rats receiving 2.5, 5, and 10 ...

The recently discovered SCFA-activated G-coupled protein receptors FFA receptor 2 and FFA receptor 3 are co-localised in L-cells with the anorexigenic ‘ileal brake’ gut hormone peptide YY, and also in adipocytes, with activation stimulating leptin release. Thus, SCFA such as acetate and propionate show promise as a candidate to increase satiety-enhancing properties of food. We therefore postula...

Parkinson disease (PD) is a neurodegenerative disease primarily characterized by cardinal motor manifestations and CNS pathology. Current drug therapies can often stabilize these cardinal motor symptoms, and attention has shifted to the other motor and nonmotor symptoms of PD that are resistant to drug therapy. Dysphagia in PD is perhaps the most important drug-resistant symptom because it lead...