RNA elements within flavivirus genomes are potential targets for antiviral therapy. A panel of phosphorodiamidate morpholino oligomers (PMOs), whose sequences are complementary to RNA elements located in the 5'- and 3'-termini of the West Nile (WN) virus genome, were designed to anneal to important cis-acting elements and potentially to inhibit WN infection. A novel Arg-rich peptide was conjuga...

BACKGROUND In Japan, postmarketing surveillance (PMS) studies are required for newly approved drug products to further collect safety information in clinical settings. "PMS study" is a general term encompassing both postmarketing observational (PMO) studies and postmarketing intervention studies for re-examination. Each PMS study is conducted under contracts between the pharmaceutical company a...

Flower-like gold nanoparticles (Au-NPs) were fabricated in surfactant-PMo(12) hybrid assemblies, where PMo(12) served as a UV-switchable reducing agent for producing Au-NPs and the organic surfactant matrices played the role of a soft template for the formation of flower-like structure of Au-NPs.

The recent slowdown in global warming has brought into question the reliability of climate model projections of future temperature change and has led to a vigorous debate over whether this slowdown is the result of naturally occurring, internal variability or forcing external to Earth's climate system. To address these issues, we applied a semi-empirical approach that combines climate observati...

Distributions of electromagnetic fields and induced forced flow inside a metal melt are crucial to understand the grain refinement driven by pulsed magneto-oscillation (PMO). In present study, PMO-induced in Ga–20wt%In–12wt%Sn liquid have been systematically investigated performing numerical simulations corresponding experimental measurements. The confirmed magnetic According simulated distribu...

The potency of antisense peptide-phosphorodiamidate morpholino oligomers (PPMOs) was improved by varying the peptide composition. An antisense phosphorodiamidate morpholino oligomer (PMO) complementary to the mRNA of the essential gene acpP (which encodes the acyl carrier protein required for lipid biosynthesis) in Escherichia coli was conjugated to the 5' ends of various cationic membrane-pene...

Penyakit TBC merupakan salah satu penyakit menular yang disebabkan oleh Mycobacterium tuberculosis menyerang paru-paru dan organ tubuh lainnya.Kepatuhan berobat faktor keberhasilan dalam penyembuhan TB paru. Salah memengaruhi kepatuhan adalah adanya Pengawas Menelan Obat (PMO). Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan PMO tentang paru dengan kejadian putus pada pend...

Four coordination networks based on the {ε-PMo(V)(8)Mo(VI)(4)O(40)(OH)(4)Zn(4)} Keggin unit (εZn) have been synthesized under hydrothermal conditions. (TBA)(3){PMo(V)(8)Mo(VI)(4)O(36)(OH)(4)Zn(4)}[C(6)H(4)(COO)(2)](2) (ε(isop)(2)) is a 2D material with monomeric εZn units connected via 1,3 benzenedicarboxylate (isop) linkers and tetrabutylammonium (TBA) counter-cations lying between the planes....

AIMS Because of its high spatial resolution and tissue contrast, magnetic resonance imaging (MRI) was used to assess cardiac structure and function in a large population of patients with acute myocardial infarction (AMI). METHODS AND RESULTS One hundred and ten patients were studied by MRI 6.1 +/- 2.2 days after AMI. Infarct size (IS), persistent microvascular obstruction (PMO), left and righ...

OBJECTIVE Peripheral blood CD34(+) cells from diabetic patients demonstrate reduced vascular reparative function due to decreased proliferation and diminished migratory prowess, largely resulting from decreased nitric oxide (NO) bioavailability. The level of TGF-beta, a key factor that modulates stem cell quiescence, is increased in the serum of type 2 diabetic patients. We asked whether transi...