Plumbagin is found in many medicinal plants and has been reported to have antimicrobial activities. We examined the molecular responses of Escherichia coli to plumbagin by using a proteomic approach to search for bacterial genes up-regulated by the drug. The protein profile obtained was compared with that of E. coli without the plumbagin treatment. Subsequent analyses of the induced proteins by...

Plumbagin, isoshinanolone, epishinanolone, shinanolone, quercetin and kaempferol were isolated from the leaves of Nepenthes gracilis. Spectral data of shinanolone are presented.

Plumbagin, 3,3'-biplumbagin and 8,8'-biplumbagin are naphthoquinones isolated by activity-directed fractionation from a Bolivian plant, Pera benensis, used in folk medicine as treatment of cutaneous leishmaniasis caused by Leishmania braziliensis. BALB/c mice were infected with L. mexicana or L. venezuelensis and treated 24 h after the parasitic infection with plumbagin (5 or 2.5 mg/kg/day), 3,...

Six quinones were isolated from the chloroform extract of the roots of Diospyros sylvatica and identified as 2-methyl-anthraquinone, plumbagin, diosindigo, diospyrin, isodiospyrin and microphyllone. The effect of the root extract on the orientation and survival of the subterranean termite, Odontotermes obesus was tested. In addition, four of these quinones were tested on the survival of the sub...

The stem barks of Pera benensis are employed by the Chimane Indians in the Bolivian Amazonia as treatment of cutaneous leishmaniasis caused by the protozoan Leishmania braziliensis. The chloroform extracts containing quinones were found active against the promastigote forms of Leishmania and the epimastigote forms of Trypanosoma cruzi at 10 micrograms ml-1. The activity guided fractionation of ...

A green study was undertaken for the extraction of plumbagin, an important natural naphthoquinone, from roots Plumbago pulchella Boiss. In first stage, four solvents were comparatively evaluated, acetone, n-hexane, ethyl acetate, and methanol; attending Principle #5, only (ethyl acetate acetone) underscored. a second step, considering # 6, various alternative activating modes assessed: two elec...

The global rise in antimicrobial resistance and lack of discovery new antimicrobials have created serious concerns. Targeting quorum sensing (QS) biofilms pathogenic bacteria is considered a promising approach drug discovery. This study explored the inhibitory effect plumbagin against QS Chromobacterium violaceum, Serratia marcescens Pseudomonas aeruginosa. Violacein production C. violaceum 124...

Kodiveli is an important Siddha drug used in the formulations such as Podi, Ennai, Thylam, Chithramoola Kuligai and Kudineer. The HPTLC a simple method to differentiate closely related species. profiling of ethanolic extracts roots three species Plumbago (Plumbago zeylanica L. (Venkodiveli), P.indica L., (Senkodiveli) P. auriculata Lam. (Karunkodiveli)) has been carried out using Toluene: Ethyl...

Plumbago scandens L. is a Brazilian tropical/subtropical species that occurs along the coast. Chemically it is mainly represented by naphthoquinones, flavonoids, terpenoids and steroids. The aim of the present work is to study quantitative changes in the root metabolic production of Plumbago scandens during different physiologic developmental stages relative to floration. The results indicated ...