Drug delivery systems (DDS) based on poly (lactide-co-glycolide) (PLGA) microspheres and nanospheres have been separately studied in previous works as a means of delivering bioactive compounds over an extended period of time. In the present study, two DDS having different sizes of the PLGA spheres were compared in morphology, drug (dexamethasone) loading efficiency and drug release kinetics in ...

Nanospheres are the particles having the size range between 10-200 nm in diameter. Nanospheres can be amorphous or crystalline in nature and also they have the ability to protect the drug from enzymatic and chemical degradation. It has been shown that the hydrophobic surfaces of these particles are highly susceptible to opsonization and clearance by the reticulo endothelial system. The tiny cap...

Novel complexation hydrogel nanospheres of poly(methacrylic acid-grafted-poly(ethylene glycol)) (P(MAA-gEG)) were prepared by dispersion polymerization to be used for protein delivery applications. Polymerization was conducted in solvents such as deionized water, ethanol/water, sodium hydroxide, hydrochloric acid, and acetic acid solutions. When polymerizing in deionized water we produced nanos...

In this study, fluconazole (FLZ) loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were prepared with two different formulations consisting of polyvinyl alcohol (PVA) and PVA-rhamnolipid (R) in order to improve antibiofilm activity against Candida albicans ATCC 90028. The encapsulation efficiency, drug loading capacity, in-vitro release, characterization these compared. Character...

Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible, biodegradable polymer approved by the FDA and EMA, which most widely used in field of health. In this study, PLGA was synthesized primarily from lactide glycolide polycondensation ring-opening polymerization. Then, amino acid derivatives were reaction acids presence 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC). The polymers PLGA, P...

The aim of the present study was to evaluate the tumor accumulation of radiolabeled long-circulating poly(ethylene glycol) (PEG)-coated hexadecylcyanoacrylate nanospheres and non-PEG-coated hexadecylcyanoacrylate nanospheres (used as control), after intravenous injection in Fischer rats bearing intracerebrally well established 9L gliosarcoma. Both types of nanospheres showed an accumulation wit...