The ameliorative activity of aqueous extract of the flesh of dates (Phoenix dactylifera L.) and ascorbic acid on thioacetamide-induced hepatotoxicity was studied in rats. Sixty male rats were divided into six equal groups of 10. Two groups were controls, one treated with thioacetamide and one with only distilled water. Two groups received extract of flesh Phoenix dactylifera and intraperitoneal...

OBJECTIVES To examine whether the activities of creatine kinase (CK) correlate with neurological disturbances caused by acrylamide. METHODS The activities of CK and other enzymes reported to be inhibited by acrylamide in the brain and plasma, and landing foot spread (LFS) were measured in mice and rats intoxicated with acrylamide. RESULTS Activity of CK was suppressed by acrylamide in the b...

Background: Probiotics have attracted a great attention aiming to develop natural non-toxic antioxidants, because of their role in decreasing the risk of reactive oxygen species (ROS) accumulation. Objectives: The purpose of this study was to assess the antioxidant activity of a probiotic Streptococcus salivarius ssp thermophillus (St.sa) and to evaluate its protective effect against the ...

Elimination of misfolded proteins is crucial for proteostasis and to prevent proteinopathies. Nedd4/Rsp5 emerged as a major E3-ligase involved in multiple quality control pathways that target misfolded plasma membrane proteins, aggregated polypeptides and cytosolic heat-induced misfolded proteins for degradation. It remained unclear how in one case cytosolic heat-induced Rsp5 substrates are des...

8-naphthylamidase and y-glutamyl transpeptidase were more complex. The leucyl-finaphthylamidase showed significant amounts of activity remaining in the sample layer with a broad distribution throughout the gradient. There were peaks of activity corresponding to 5'-nucleotidase (plasma membrane), N-acetyl-fi-glucosaminidase (lysosomal) and neutral a-glucosidase (microsomal) suggesting a multi-or...

introduction: it has been shown that the extract of elaeagnus angustifolia can inhibit inflammation and pain induced by formalin in mice and rats. the aim of the present study is to reach evaluations of possible cellular and molecular mechanisms of elaeagnus angustifolia extract in reducing pain and inflammation through examining the extract ability for inhibition of cyclooxygenase (cox) type 1...

Background: Aspirin use is extensive, but its short half-life limits bioavailability. Results: Butyrylcholinesterase and PAFAH1b2 hydrolyze aspirin in plasma. Aspirin hydrolysis in plasma varies up to 12-fold from non-genetic modulation of butyrylcholinesterase activity. Conclusion: Two enzymes hydrolyze aspirin in plasma and their contribution varies among individuals. Significance: Aspirin hy...

A histochemical method is described of differentiating between normal and neoplastic cells in plasma using the activity of various enzymes characteristic of plasma cells. It was found that in both types of cell increased or diminished activity of cytoenzymes is a useful means of distinguishing between normal and abnormal cells.

The objective of the research was to study signs oxidative stress, state proteolysis, and proteinase-inhibiting system blood plasma in rats with streptozotocin-induced diabetes mellitus (60 mg/kg intra-abdominally), complicated by cerebral ischemia-reperfusion. Levels products lipid peroxide oxidation, protein modification, nitrogen oxide metabolites, activity antioxidant protection enzymes wer...