BACKGROUND While oral tacrolimus is effective for the treatment of psoriasis, tacrolimus ointment has shown only spotty efficacy in the treatment of plaque psoriasis. The efficacy of tacrolimus ointment for the treatment of facial and intertriginous psoriasis suggests that if tacrolimus penetration can be increased, the ointment could be used for effective treatment of plaque psoriasis. OBJEC...

The development of several highly effective biologic drugs in the past decade has revolutionized the treatment of moderate-to-severe plaque psoriasis. With increased understanding of the immunopathogenesis of psoriasis, the emphasis has turned toward more specific targets for psoriasis drugs. Although the complex immunological pathway of psoriasis is not yet completely understood, current model...

Background: Plaque psoriasis is one of the most common forms of psoriasis. Since psoriasis is an inflammatory condition with high oxidative stress, the patients with psoriasis seem to be vulnerable for the development of atherosclerosis, hypertension and coronary artery disease.Electrocardiographic P-wave changes are considered as significant marker of myocardial stress. Methods and materials: ...

1. Puig L, Carrascosa JM, Carretero G, de la Cueva P, Lafuente-Urrez RF, Belinchón I, et al. Directrices españolas basadas en la evidencia para el tratamiento de la psoriasis con agentes biológicos, 2013. I. Consideraciones de eficacia y selección del tratamiento. Actas Dermosifiliogr. 2013;104:694--709. 2. Ferrandiz C, García A, Blasco AJ, Lázaro P. Cost-efficacy of adalimumab, etanercept, inf...

This is a case of 42 years female presented with the complain extreme dryness soles and fingers feet for 2 years. She also complained burning on sides toes, cracks both intense itching. After systematic taking followed by repertorisation totality Synthesis Repertory using RADAR software in order to choose individualised remedy.

INTRODUCTION Psoriasis, whose relation with atherosclerosis etc. has long been known, is a chronic inflammatory disease. Besides providing hemostasis, platelets play important roles in inflammatory reactions and immune responses and contribute to endothelial damage, thus leading to atherosclerotic plaque formation. Mean platelet volume (MPV) has been previously reported as a platelet activation...

be no personal or family history of typical chronic plaque psoriasis lesionselsewhereonthebody,nohistoryofatopic dermatitis, and no relevant positive findings on patch testing. Patients were considered to have palmoplantar psoriasis if they presented with well-demarcated, symmetric, indurated, and hyperkeratotic plaques on the palms with asharpcutoff at thewrist.Patientswereconsidered tohave ty...

The origin is characterised by skin and nail spots. It considered a serious condition that affects around 100 million people worldwide. In 2016 - 2017, 2% of the global population 0.44-2.8% Indian were affected with psoriasis. five most common kinds psoriasis are plaque, guttate, inverted, pustular, erythrodermic. Plaque psoriasis, also known as vulgaris, prevalent type illness (about 90% cases...

Secukinumab (Cosentyx™) is a human monoclonal IgG1k antibody that has been developed to target and block the actions of IL-17A. It is known that this cytokine is elevated in lesions of psoriasis. Interleukins in the Th17 pathway play a pivotal role in the pathogenesis of psoriasis and have thus become targets for recent biologic drug development. As a monoclonal antibody immune modulator, secuk...