Epidemiological and experimental studies indicate a strong association between an elevated colon cancer risk and increased fecal excretion of secondary bile acids, neutral sterols, and prolonged gastrointestinal transit time. Starch malabsorption, on the other hand, has been reported to be a possible protective factor in colon carcinogenesis. To study the impact of starch malabsorption on these...

AIM To evaluate the long-term effectiveness of rivastigmine patch or capsule on mild to severe Alzheimer's disease (AD). METHOD We performed a meta-analysis of 17 studies regarding the treatment effectiveness of rivastigmine patch or capsule on mild-to-severe AD. RESULTS Significant difference exists between treatment with rivastigmine patch or capsule and placebo groups (p-value < 0.001). ...

Objective: The purpose of this study was to determine the effects 6-week consumption anthocyanin-containing supplement on eye function.Methods: This a randomized, placebo-controlled, double-blind, parallel-group comparison involving 32 healthy Japanese adults with fatigue after using visual display terminals (VDTs). Subjects were randomly allocated into either active group (bilberry-derived ant...

objective: zinc is the second main element in the body after iron. its importance in pregnancy is related to role in dna and protein synthesis and consequently the necessity of its availability for the appropriate growth and development of the fetus and neonate. the purpose of this study was to assess the effect of zinc supplement on fetal outcomes (height, weight, head and chest circumference ...

BACKGROUND Aged garlic extract (AGE) and coenzyme Q10 (CoQ10) have been shown to affect multiple cardiovascular risk factors. The current study evaluates the effect of AGE combined with CoQ10 on inflammatory markers and progression of coronary atherosclerosis compared with placebo. METHODS AND RESULTS In this placebo-controlled, double-blind, randomized trial, 65 intermediate risk firefighter...

Buspirone is a serotonin 5-HT(1A) receptor agonist licensed for the treatment of anxiety. Other anxiolytic drugs such as benzodiazepines show significant sedative and other unwanted effects on cognition. Studies to date have yet to investigate cognitive effects of buspirone using well-validated computerized tests. The aim of this study was to assess acute subjective and cognitive effects of bus...

BACKGROUND Previous case-control and prospective studies have shown an association between the presence of periodontitis and the risk of preterm birth (PTB). The goal of this pilot trial was to determine the feasibility of conducting a trial to determine whether treatment of periodontitis reduces the risk of spontaneous preterm birth (SPTB). METHODS Three hundred sixty-six (366) women with pe...

BACKGROUND Vascular risk factors (VRF) may influence response to rivastigmine in Alzheimer's disease (AD). METHODS AD patients who participated in a randomized, double-blind, placebo-controlled trial of rivastigmine patch and capsule treatment were stratified by baseline VRF status. Treatment response was evaluated using the AD Assessment Scale-cognitive subscale (ADAS-cog), AD Cooperative St...

One billion human adults worldwide are overweight and, thus, more prone to develop cardiovascular diseases, diabetes, and a variety of other chronic contidions. . Dietary supplements that inhibit gastrointestinal amylase are referred to as “starch blockers,” and have been associated with weight loss. Starch blockers may promote weight loss by interfering with breakdown of complex carbohydrates ...

This study was designed to determine the therapeutic efficacy and safety of the Shi-cha capsule, a Chinese herbal formula, in the treatment of patients with wind-cold type common cold. In our multi-center, prospective, double-blind, randomized, placebo-controlled, dose-escalation trial, patients with wind-cold type common cold received 0.6 g of Shi-cha capsule plus 0.6 g placebo (group A), 1.2 ...